An outbreak of sheep-associated Q fever in a rural community in Germany
An outbreak of sheep-associated Q fever in a rural community in Germany
复制标题
DOI：
10.1023/a:1007452503863
复制
发表时间：
1998-02-01
影响因子：
13.6
通讯作者：
Petersen, L
中科院分区：
文献类型：
--
作者：
Lyytikainen, O;Ziese, T;Petersen, L
1996年春，在德国一个农村城镇（人口：300人）的居民中发生了Q热暴发。进行了一项回顾性队列研究，以确定疫情的范围，并评估疾病的潜在风险因素。1996年7月，所有大于或等于15岁的居民收到了一份自填问卷，并提供了贝氏柯克斯体抗体检测。如果居民的IgM C结果呈阳性，则认为他们可能患有Q热。如果在1996年1月1日之后有发热大于或等于39摄氏度，持续>2天，并且有大于或等于3种症状（寒战、出汗、严重头痛、咳嗽、肌肉/关节疼痛、背痛、疲劳或感觉不适），则可以通过ELISA检测贝氏体抗体或可能的Q热。在239名年龄大于或等于15岁的居民中，有200人（84%）完成了问卷调查或提交了血液进行抗体检测。这200例中有45例（23%）符合很可能或可能病例定义。1996年1月至6月发病。病例在地理上分布在整个城镇。报告与绵羊接触（32% vs 18%，RR：1.8，95% CI：1.1-2.9）和在城镇附近的大型羊场附近行走（34% vs 8%，RR：4.5，95% CI：1.7-12.2）的人比没有这些接触的人更可能符合病例定义。20份大规模羊群样品中有15份C.伯氏体抗体1995年12月至1996年1月，当天气非常干燥时，绵羊在户外产羔。产羔后暴发的时间、病例在整个城镇的均匀分布以及大多数病例中没有危险因素表明C.来自大型绵羊养殖场的伯内特
In spring 1996, an outbreak of Q fever occurred among residents of a rural town (population: 300) in Germany. A retrospective cohort study was conducted to ascertain the extent of the outbreak and to assess potential risk factors for illness. In July 1996, all residents greater than or equal to 15 years received a self-administered questionnaire and were offered Coxiella burnetii antibody testing. Residents were considered to have probable Q fever if they had a positive result for IgM C. burnetii antibodies by ELISA or possible Q fever if they had fever greater than or equal to 39 degrees C lasting >2 days and greater than or equal to 3 symptoms (chills, sweats, severe headache, cough, aching muscles/joints, back pain, fatigue, or feeling ill) after 1 January 1996. Two hundred (84%) of the 239 residents aged greater than or equal to 15 years either completed the questionnaire or submitted blood for antibody testing. Forty-five (23%) of these 200 met the probable or possible case definitions. Onsets of illness occurred in January-June 1996. Cases were geographically distributed throughout the town. Persons reporting contact with sheep (32% vs 18%, RR: 1.8, 95% CI: 1.1-2.9) and walking near a large sheep farm located next the town (34% vs 8%, RR: 4.5, 95% CI: 1.7-12.2) were more likely to have met the case definition than those without these exposures. Fifteen of 20 samples from the large sheep flock were positive for C. burnetii antibodies. The sheep had lambed outdoors in December 1995-January 1996 while the weather was extremely dry. The timing of the outbreak after lambing, the uniform distribution of cases thoughout the town and the absence of risk factors among most case-persons suggest airborne transmission of C. burnetii from the large sheep farm.