RISK-FACTORS FOR LATE-ONSET ALZHEIMERS-DISEASE - A POPULATION-BASED, CASE-CONTROL STUDY
RISK-FACTORS FOR LATE-ONSET ALZHEIMERS-DISEASE - A POPULATION-BASED, CASE-CONTROL STUDY
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DOI：
10.1002/ana.410330306
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发表时间：
1993-03-01
影响因子：
11.2
通讯作者：
WINBLAD, B
中科院分区：
文献类型：
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作者：
FRATIGLIONI, L;AHLBOM, A;WINBLAD, B
我们目前对阿尔茨海默病风险因素的了解有限，主要针对早发性疾病。本研究旨在通过病例对照法确定迟发性阿尔茨海默病的危险因素。从斯德哥尔摩正在进行的关于老龄化和痴呆症的人口调查（Kungsholmen项目）中收集了98例病例和216例对照。我们发现，至少有一位一级亲属患有痴呆症，相对风险较高（3.2；95%可信区间为1.8-5.7）。在所有其他危险因素中，酗酒（相对危险度为4.4；95%可信区间为1.4-13.8）和体力劳动（男性相对危险度为5.3；95%可信区间为1.1-25.5）是正相关的。未发现与帕金森病家族史、父母分娩年龄、出生季节或既往头部创伤有明显关联。总之，我们的数据表明，迟发性阿尔茨海默病的主要危险因素是痴呆家族史，正如之前报道的早发性疾病一样。此外，酒精滥用和职业暴露可能对这种疾病起特殊作用。
Our current knowledge of risk factors for Alzheimer's disease is limited and primarily addresses early-onset disease. This study aimed to determine the risk factors for late-onset Alzheimer's disease using a case-control approach. Ninety-eight cases and 216 controls were gathered from an ongoing population survey on aging and dementia in Stockholm (the Kungsholmen Project). We found a high relative risk (3.2; 95% confidence interval, 1.8-5.7) with the presence of at least one first-degree relative affected by dementia. Among all the other risk factors, alcohol abuse (relative risk, 4.4; 95% confidence interval, 1.4-13.8) and manual work (relative risk for men of 5.3; 95% confidence interval, 1.1-25.5) emerged as positively associated. No clear association was found with a family history of Parkinson disease, advanced parental age at index delivery, season of birth, or previous head trauma. In conclusion, our data suggest that the main risk factor for late-onset Alzheimer's disease is a family history of dementia, as has been previously reported for early-onset disease. Moreover, alcohol abuse and occupational exposure might play a specific role for this form of the disease.