Measurement of tumor blood flow by deuterium NMR and the effects of modifiers.
Measurement of tumor blood flow by deuterium NMR and the effects of modifiers.
复制标题
通过氘核磁共振测量肿瘤血流量和修饰剂的作用。
DOI：
10.1002/nbm.1940050516
复制
发表时间：
1992
影响因子：
2.9
通讯作者：
Evelhoch,JL
中科院分区：
文献类型：
--
作者：
Evelhoch,JL
肿瘤代谢与肿瘤血流量直接相关，新陈代谢和血流量可能是肿瘤治疗反应的决定因素。由于核磁共振已被广泛用于非侵入性监测肿瘤代谢，基于核磁共振的TBF测量方法的发展是为了研究肿瘤代谢和血流作为治疗反应的决定因素所起的作用。1987年，Ackerman和他的同事(Proc.)提出了使用氚水作为核磁共振可检测的限流示踪剂来测量组织血流量(或毛细血管灌注)的概念。自然，阿卡德。科学版，USA84,4099-4102(1987))。从那时起，已经设计出了使用光谱和成像检测的方法来测量基于氚水的清除或吸收的TBF。一般来说，清除方法更容易实施，而摄取方法对肿瘤的侵袭性较小。当适当谨慎使用时，两种方法都会产生可靠的结果。到目前为止，这些方法只应用于数量相对有限的动物肿瘤。然而，它们的使用正在增加，其中一些方法最终应该适用于人类肿瘤。
Tumor metabolism is directly coupled to tumor blood flow (TBF) and both metabolism and blood flow may be determinants of tumor response to treatment. Since NMR has been used extensively to monitor tumor metabolism noninvasively, development of NMR‐based methods for TBF measurement was motivated by the desire to examine the roles tumor metabolism and blood flow may play as determinants of therapeutic response. The concept of using deuterated water as an NMR‐detectable, flow‐limited tracer for the measurement of tissue blood flow (or capillary perfusion) was introduced in 1987 by Ackerman and coworkers (Proc. Natl., Acad. Sci., USA84, 4099–4102 (1987)). Since that time, methods have been devised using both spectroscopic and imaging detection for TBF measurement based on either clearance or uptake of deuterated water. In general, the clearance methods are more straightforward to implement, while the uptake methods are less invasive to the tumor. When used with appropriate caution, both approaches yield reliable results. To date, these methods have been applied in a relatively limited number of animal tumors. However, their use is increasing and some of these methods ultimately should be applicable in human tumors.