Breath methane excretion in patients with unresected colorectal cancer.
Breath methane excretion in patients with unresected colorectal cancer.
复制标题
未切除的结直肠癌患者的呼吸甲烷排泄。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
G. Potter
中科院分区：
文献类型：
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作者：
D. Karlin;R. Jones;J. Stroehlein;A. Mastromarino;G. Potter
我们研究的目的是验证或驳斥这样的观察，即未切除的结直肠癌患者比普通人群更有可能是呼气甲烷排泄者。结肠内血红素对口服血红蛋白的11名正常志愿者的呼气甲烷排泄量无影响。泻剂灌肠结肠镜检查准备对随后的呼气甲烷测量有深远的影响。4例自愿排泄者中，3例无排泄者，2例分别持续21天和7个月。55例未切除的结直肠癌患者和99例正常对照的甲烷排泄率和呼气量均无显著差异。然而，13例未切除的降结肠癌或乙状结肠癌患者呼气甲烷排泄物的可能性几乎是38例其他部位结直肠癌患者的两倍。
The objective of our study was to verify or refute the observation that patients with unresected colorectal cancer are more likely to be breath methane excretors than the general population. Intracolonic heme had no effect on breath methane excretion of 11 normal volunteers given oral hemoglobin. Laxative-enema colonoscopy preparation had a profound effect on the subsequent measurement of breath methane. Three of 4 volunteer methane excretors became nonexcretors, and 2 remained nonexcretors for 21 days and 7 months, respectively. No significant difference was found in the frequency and the amount of breath methane excretion in 55 patients with unresected colorectal cancer and in 99 control subjects. However, 13 patients with unresected descending or sigmoid colon cancers were almost twice as likely to be breath methane excretors as 38 patients with colorectal cancer at other sites.