Cumulative neonatal oxygen exposure predicts response of adult mice infected with influenza A virus.
Cumulative neonatal oxygen exposure predicts response of adult mice infected with influenza A virus.
复制标题
新生小鼠的累积氧气暴露量可预测感染甲型流感病毒的成年小鼠的反应。
DOI：
10.1002/ppul.23063
复制
发表时间：
2015
影响因子：
3.1
通讯作者：
O'Reilly,MichaelA
中科院分区：
文献类型：
--
作者：
Maduekwe,EchezonaT;Buczynski,BradleyW;Yee,Min;Rangasamy,Tiruamalai;Stevens,TimothyP;Lawrence,BPaige;O'Reilly,MichaelA
An acceptable level of oxygen exposure in preterm infants that maximizes efficacy and minimizes harm has yet to be determined. Quantifying oxygen exposure as an area‐under‐the curve (OAUC) has been predictive of later respiratory symptoms among former low birth weight infants. Here, we test the hypothesis that quantifying OAUCin newborn mice can predict their risk for altered lung development and respiratory viral infections as adults. Newborn mice were exposed to room air or a FiO2of 100% oxygen for 4 days, 60% oxygen for 8 days, or 40% oxygen for 16 days (same cumulative dose of excess oxygen). At 8 weeks of age, mice were infected intranasally with a non‐lethal dose of influenza A virus. Adult mice exposed to 100% oxygen for 4 days or 60% oxygen for 8 days exhibited alveolar simplification and altered elastin deposition compared to siblings birthed into room air, as well as increased inflammation and fibrotic lung disease following viral infection. These changes were not observed in mice exposed to 40% oxygen for 16 days. Our findings in mice support the concept that quantifying OAUCover a currently unspecified threshold can predict human risk for respiratory morbidity later in life.Pediatr Pulmonol. 2015; 50:222–230.© 2014 Wiley Periodicals, Inc.
