Some factors in the morphogenesis of vertebrate embryonic epithelia
Some factors in the morphogenesis of vertebrate embryonic epithelia
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脊椎动物胚胎上皮形态发生的一些因素
DOI：
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发表时间：
1937
期刊：
影响因子：
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通讯作者：
F. C. Sauer
中科院分区：
文献类型：
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作者：
F. C. Sauer
本文将作者之前关于胚胎柱状上皮的工作的各个方面联系起来，并特别讨论了决定上皮形式的机械因素。讨论了终端杆的起源、终端杆呈现的各种形式以及终端杆网在维持上皮结构中的重要性。论文还详细考虑了柱状细胞分裂后的伸长情况。当这种形状的变化不能归因于外部的拥挤时，表明伸长纺锤纤维的推力作用是造成的内力。在任何一种情况下，伸长率都受到限制自由表面的终端网的发展的影响。作者于 1935 年首次描述了对该结构的进一步观察。末端网通常存在于柱状上皮中，是固定细胞质的特殊部分，浓缩并位于末端条的平面中。它在有丝分裂中消失，但随着新细胞伸长而重新出现，限制了细胞自由端的面积。因此，终端网在确定柱状细胞的形状方面起着重要作用。
This paper correlates the various aspects of the author's previous work on embryonic columnar epithelia and deals especially with the mechanical factors that determine the form of an epithelium. The origin of the terminal bars, the various forms the terminal bars assume, and the significance of the terminal bar net in maintaining the epithelial structure are discussed. The paper also gives detailed consideration to the elongation of columnar cells after division. When this change in shape cannot be attributed to crowding from without, it is suggested that a thrusting action of elongating spindle fibers is the internal force responsible. In either case elongation is influenced by the development of the terminal web limiting the free surface. Further observations on this structure, first described by the author in 1935, are presented. The terminal web, which is generally present in columnar epithelia, is a specialized part of fixed cytoplasm, condensed, and lying in the plane of the terminal bars. It disappears in mitosis, but its reappearance as the new cell elongates limits the area of the free end of the cell. Hence, the terminal web plays an important part in determining the form of columnar cells.