Characterization of Neisseria meningitidis strains causing disease in complement-deficient and complement-sufficient patients
Characterization of Neisseria meningitidis strains causing disease in complement-deficient and complement-sufficient patients
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DOI：
10.1128/jcm.36.8.2342-2345.1998
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发表时间：
1998-08-01
影响因子：
9.4
通讯作者：
Caugant, DA
中科院分区：
文献类型：
--
作者：
Fijen, CAP;Kuijper, EJ;Caugant, DA
脑膜炎球菌的血清分型和血清亚型在44个补体缺乏者和50个补体充足的脑膜炎球菌病患者的分离株之间没有差别。脑膜炎双球菌的多位点酶电泳型分析显示，54种电泳型在补体缺乏和补体充足患者的分离株中均匀分布。对从8名患有11次脑膜炎双球菌病复发的补体缺乏者分离的菌株的分析表明，有一种菌株与以前从同一人身上分离的菌株相同。我们的结果表明，感染补体缺乏患者和补体充足患者的菌株克隆分布没有差异。大多数复发是由不同菌株引起的感染。
Serotyping and serosubtyping of meningococci showed no difference between isolates from 44 complement-deficient persons and from 50 complement-sufficient persons with meningococcal disease. Multilocus enzyme electrophoretic typing of the meningococci revealed 54 electrophoretic types that were equally distributed among isolates from complement-deficient and complement-sufficient patients. Analysis of strains isolated from eight complement-deficient persons with 11 recurrences of meningococcal disease showed that one strain ias identical to the strain previously isolated from the same individual. Our results indicate that there are no differences between the clonal distributions of strains infecting complement-deficient and complement-sufficient patients. Most recurrences were infections caused by different strains.