CELLULAR REACTIONS TO IMPLANTATION OF A MICRODIALYSIS TUBE IN THE RAT HIPPOCAMPUS
CELLULAR REACTIONS TO IMPLANTATION OF A MICRODIALYSIS TUBE IN THE RAT HIPPOCAMPUS
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DOI：
10.1007/bf00688186
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发表时间：
1987-01-01
影响因子：
12.7
通讯作者：
DIEMER, NH
中科院分区：
文献类型：
--
作者：
BENVENISTE, H;DIEMER, NH
将用于测定细胞外神经递质浓度的微透析管植入大鼠背侧海马，以研究邻近组织的反应。植入后1 - 60天检查大脑。在最初的2天内，微透析管周围的神经纤维组织正常，仅偶尔出血。移植后3天星形胶质细胞靠近透析管，肥大。肥大的星形胶质细胞突起侵入海绵状纤维壁。 星形胶质细胞的数量没有增加。14天后，纤维插入层的网状蛋白阳性纤维分离星形胶质细胞和其余的神经胶质细胞从纤维壁。晚期组织变化（1和2个月）包括胶原沉积和偶尔的肉芽肿形成。这些结果可用于预测纤维植入后开始微透析的最佳时间。
Microdialysis tubes, used for measurements of extracellular neurotransmitter concentrations, were implanted in rat dorsal hippocampus to study the adjacent tissue reaction. The brain was examined 1 - 60 days after the implantation. Within the first 2 days, normal neuropil and only occasional hemorrhage surrounded the microdialysis tube. Three days following the implantation astrocytes close to the dialysis tube, hypertrophied. Hypertrophic astrocyte processes invaded the spongy fiber wall. There was no increase in the number of astrocytes. Fourteen days after the fiber insertion layers of reticulin-positive fibers separated astrocytes and the remaining neuropil from the fiber wall. Late tissue changes (1 and 2 months) consisted of collagen deposits and occasional granuloma formation. These results can be used to predict the optimal time for commencing microdialysis after the fiber implantation.