D'Amico Risk Stratification Correlates With Degree of Suspicion of Prostate Cancer on Multiparametric Magnetic Resonance Imaging
D'Amico Risk Stratification Correlates With Degree of Suspicion of Prostate Cancer on Multiparametric Magnetic Resonance Imaging
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DOI：
10.1016/j.juro.2010.10.076
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发表时间：
2011-03-01
影响因子：
6.6
通讯作者：
Pinto, Peter A.
中科院分区：
文献类型：
--
作者：
Rastinehad, Ardeshir R.;Baccala, Angelo A., Jr.;Pinto, Peter A.
目的：基于使用我们的电磁跟踪磁共振成像/超声融合平台进行的靶向活检，我们确定了 D'Amico 风险分层与多参数磁共振成像怀疑前列腺癌的程度之间是否存在相关性。材料和方法：总共 101 名患者接受了 3 特斯拉多参数磁共振成像，包括 T2、动态对比增强、扩散加权和光谱图像，适用于怀疑或诊断为前列腺癌的病例。然后根据阳性模式的数量对所有前列腺磁共振成像病变进行识别和分级，包括在多参数磁共振成像上显示可疑的低2或更少、中3和高4。活检方案包括标准 12 芯活检，然后对可疑磁共振病变进行实时磁共振成像/超声融合靶向活检。通过 D'Amico 风险分层对病例和病变进行分层。结果：在本次筛查人群中，90.1% 的男性直肠指检呈阴性。平均+/- SD年龄为62.7 +/- 8.3岁，中位前列腺特异性抗原为5.8 ng/ml。在这些病例中，54.5% 的活检结果呈癌症阳性。卡方分析揭示了磁共振怀疑与 D'Amico 风险分层之间存在统计显着相关性 (p
Purpose: We determined whether there is a correlation between D'Amico risk stratification and the degree of suspicion of prostate cancer on multiparametric magnetic resonance imaging based on targeted biopsies done with our electromagnetically tracked magnetic resonance imaging/ultrasound fusion platform.Materials and Methods: A total of 101 patients underwent 3 Tesla multiparametric magnetic resonance imaging of the prostate, consisting of T2, dynamic contrast enhanced, diffusion weighted and spectroscopy images in cases suspicious for or with a diagnosis of prostate cancer. All prostate magnetic resonance imaging lesions were then identified and graded by the number of positive modalities, including low-2 or fewer, moderate-3 and high-4 showing suspicion on multiparametric magnetic resonance imaging. The biopsy protocol included standard 12-core biopsy, followed by real-time magnetic resonance imaging/ultrasound fusion targeted biopsies of the suspicious magnetic resonance lesions. Cases and lesions were stratified by the D'Amico risk stratification.Results: In this screening population 90.1% of men had a negative digital rectal examination. Mean +/- SD age was 62.7 +/- 8.3 years and median prostate specific antigen was 5.8 ng/ml. Of the cases 54.5% were positive for cancer on protocol biopsy. Chi-square analysis revealed a statistically significant correlation between magnetic resonance suspicion and D'Amico risk stratification (p