High-Throughput Optimization of Ir-Catalyzed C-H Borylation: A Tutorial for Practical Applications
High-Throughput Optimization of Ir-Catalyzed C-H Borylation: A Tutorial for Practical Applications
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DOI：
10.1021/ja400295v
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发表时间：
2013-05-22
影响因子：
15
通讯作者：
Smith, Milton R., III
中科院分区：
文献类型：
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作者：
Preshlock, Sean M.;Ghaffari, Behnaz;Smith, Milton R., III
借助于高通量筛选，Ir催化的C-H硼化反应的效率已被评估为预催化剂，硼试剂，配体，添加顺序，温度，溶剂和底物的函数。这项研究不仅验证了一些公认的做法，但也发现了非常规的条件下，基板性能的关键。我们预计，从这些研究结果中得出的见解将被用来设计反应条件的基板的硼化是很难不可能使用标准的催化条件。
With the aid of high-throughput screening, the efficiency of Ir-catalyzed C-H borylations has been assessed as functions of precatalyst, boron reagent, ligand, order of addition, temperature, solvent, and substrate. This study not only validated some accepted practices but also uncovered unconventional conditions that were key to substrate performance. We anticipate that insights drawn from these findings will be used to design reaction conditions for substrates whose borylations are difficult to impossible using standard catalytic conditions.