Cystometric evaluation of bladder function in nonanesthetized mice with and without bladder outlet obstruction
Cystometric evaluation of bladder function in nonanesthetized mice with and without bladder outlet obstruction
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DOI：
10.1016/s0022-5347(05)67204-7
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发表时间：
2000-10-01
影响因子：
6.6
通讯作者：
Andersson, KE
中科院分区：
文献类型：
--
作者：
Pandita, RK;Fujiwara, M;Andersson, KE
目的：建立一种研究清醒小鼠膀胱功能的模型，并对非梗阻和膀胱下梗阻小鼠膀胱进行尿动力学和免疫组织化学研究。材料和方法：非梗阻Balb/CJ小鼠和术后出现膀胱出口梗阻的小鼠，部分结扎大鼠的尿路，进行连续的膀胱测量。结果：在膀胱测压的标题期间，获得了可重复性的排尿模式。非梗阻小鼠与梗阻小鼠的尿流动力学参数有显著差异。在发生尿路梗阻的小鼠中，排尿压力(p
Purpose: To develop a model for cystometric study of bladder function in the awake mouse, and to characterize urodynamically and immunohistochemically the non-obstructed and infravesically obstructed mouse bladder.Materials and Methods: Non-obstructed Balb/CJ mice, and mice with bladder outlet obstruction after surgical, partial ligation of the urethra underwent continuous cystometry as previously described for rats. Bladders were also investigated by immunohistochemistry.Results: During title period of cystometry, reproducible micturition patterns were obtained. Marked differences in the urodynamic parameters between non-obstructed and obstructed mice were revealed. In mice subjected to urethral obstruction, micturition pressure (p