No evidence for an involvement of alleles of polymorphisms in the serotonin1Dβ and 7 receptor genes in obesity, underweight or anorexia nervosa
No evidence for an involvement of alleles of polymorphisms in the serotonin1Dβ and 7 receptor genes in obesity, underweight or anorexia nervosa
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DOI：
10.1038/sj.ijo.0800926
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发表时间：
1999-07-01
影响因子：
4.9
通讯作者：
Hebebrand, J
中科院分区：
文献类型：
--
作者：
Hinney, A;Herrmann, H;Hebebrand, J
多巴胺能（5-羟色胺，5-HT）系统与体重调节和神经性厌食症（AN）的病因有关。在这里，我们描述了5-HT 1D β受体基因中已知的Phe-124-Cys多态性和5-HT 7受体基因中已知的Pro-279-Leu多态性的筛选。为了进行关联性检验，我们比较了393名极度肥胖儿童和青少年、142名体重不足学生和84名AN患者的等位基因频率。相关性检验均未显示标称P值低于0.3。我们的结论是一个主要的作用，研究多态性在体重调节或AN似乎不太可能。
The serotonergic (5-hydroxytryptamine, 5-HT) system has been implicated in body weight regulation and in the etiology of anorexia nervosa (AN). Here we describe the screening of the known Phe-124-Cys polymorphism in the 5-HT1D beta receptor gene and of the known Pro-279-Leu polymorphism in the 5-HT7 receptor gene. For association tests allele frequencies were compared between up to 393 extremely obese children and adolescents, 142 underweight students and 84 patients with AN. None of the association tests revealed nominal P-values below 0.3. We conclude that a major role of the investigated polymorphisms in body weight regulation or AN appears unlikely.