Roles of H3K36-specific histone methyltransferases in transcription: antagonizing silencing and safeguarding transcription fidelity.
Roles of H3K36-specific histone methyltransferases in transcription: antagonizing silencing and safeguarding transcription fidelity.
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DOI：
10.1007/s41048-018-0063-1
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发表时间：
2018
影响因子：
--
通讯作者：
Zhu B
中科院分区：
文献类型：
--
作者：
Huang C;Zhu B
组蛋白H3K36甲基化因其在活性转录中的作用而众所周知。在酿酒酵母中，H3K36甲基化在转录延伸期间仅由SET 2介导。在后生动物中，存在多种H3K36特异性甲基转移酶，并有助于不同的生化活性和后续功能。本文综述了后生动物中H3K36特异性组蛋白甲基转移酶的研究进展，并讨论了其酶活性调控及其在拮抗Polycomb沉默和保护转录保真度中的作用。
Histone H3K36 methylation is well-known for its role in active transcription. In Saccharomyces cerevisiae, H3K36 methylation is mediated solely by SET2 during transcription elongation. In metazoans, multiple H3K36-specific methyltransferases exist and contribute to distinct biochemical activities and subsequent functions. In this review, we focus on the H3K36-specific histone methyltransferases in metazoans, and discuss their enzymatic activity regulation and their roles in antagonizing Polycomb silencing and safeguarding transcription fidelity.