A first Japanese case of BRCA2 and RB1 co-loss organ-confined prostate cancer successfully treated by radical prostatectomy
A first Japanese case of BRCA2 and RB1 co-loss organ-confined prostate cancer successfully treated by radical prostatectomy
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日本首例 BRCA2 和 RB1 共丢失器官局限性前列腺癌通过根治性前列腺切除术成功治愈
DOI：
10.1007/s13691-021-00469-z
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发表时间：
2021
影响因子：
0.7
通讯作者：
Oya Mototsugu
中科院分区：
文献类型：
--
作者：
Matsumoto Kazuhiro;Kosaka Takeo;Nakamura Kohei;Nishihara Hiroshi;Oya Mototsugu
我们报告一例罕见的伴有BRCA2和RB1共同缺失的局限性前列腺癌，通常在较晚期发现，预后较差。1例59岁男性前列腺癌患者被转诊至本院接受手术治疗。他患有精神分裂症，药物可以很好地控制这种疾病。他没有前列腺癌、乳腺癌或卵巢癌的家族病史。他最初的前列腺特异性抗原为4.5ng.mLGleason评分为3 + 4的12个穿刺点中的一个发现了腺癌。影像检查证实临床分期为cT2aN0M0。因此，采用机器人辅助的保留双侧神经的腹腔镜前列腺癌根治术(RALP)。病理组织学Gleason评分为4 + 3，病理分期为pT2N0M0，切缘阴性。基因测序证实BRCA2和RB1共缺失，异质性损失有限(LOH)。在手术后12个月，他的PSA水平仍保持在 <； 0.01g/mL。此病例提示早期发现前列腺癌的重要性以及治愈具有高恶性潜能的前列腺癌的可能性。
We report a rare case of localized prostate cancer withBRCA2andRB1co-loss, which is usually found at a more advanced stage with a poor prognosis. A 59-year-old male with prostate cancer was referred to our hospital for surgical treatment. He had schizophrenia that was well controlled by medicine. He had no family history of prostate cancer, breast cancer, or ovarian cancer. His initial PSA was 4.5 ng/mL, and Gleason score 3 + 4 adenocarcinoma was detected in one of 12 needle biopsy cores. Imaging studies demonstrated the clinical stage to be cT2aN0M0. Therefore, robot-assisted laparoscopic radical prostatectomy (RALP) with bilateral nerve sparing was performed. Based on histopathological analysis, the Gleason score was 4 + 3 and the pathological stage was pT2N0M0 with a negative surgical margin. Genetic sequencing identifiedBRCA2andRB1co-loss with limited loss of heterogeneity (LOH). At 12 months after surgery, his PSA level remained < 0.01 ng/mL. This case suggests the importance of early detection of prostate cancer and the possibility of cure for prostate cancer with high malignant potential.
影响因子：
4.6
作者：
Abida W;Armenia J;Gopalan A;Brennan R;Walsh M;Barron D;Danila D;Rathkopf D;Morris M;Slovin S;McLaughlin B;Curtis K;Hyman DM;Durack JC;Solomon SB;Arcila ME;Zehir A;Syed A;Gao J;Chakravarty D;Vargas HA;Robson ME;Joseph V;Offit K;Donoghue MTA;Abeshouse AA;Kundra R;Heins ZJ;Penson AV;Harris C;Taylor BS;Ladanyi M;Mandelker D;Zhang L;Reuter VE;Kantoff PW;Solit DB;Berger MF;Sawyers CL;Schultz N;Scher HI
通讯作者：
Scher HI
影响因子：
3.8
作者：
Jasin M;Haber JE
通讯作者：
Haber JE