Both motor and sensory abnormalities contribute to changes in foot posture in an experimental rat neuropathic model
Both motor and sensory abnormalities contribute to changes in foot posture in an experimental rat neuropathic model
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DOI：
10.1016/0304-3959(96)03103-x
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发表时间：
1996-09-01
期刊：
影响因子：
7.4
通讯作者：
Chung, JM
中科院分区：
文献类型：
--
作者：
Na, HS;Yoon, YW;Chung, JM
本研究旨在探讨疼痛是否会导致表现神经性疼痛行为的大鼠的足部姿势异常，如果是，是否存在反映疼痛程度的特定异常。我们使用了一个大鼠神经性疼痛模型，该模型是通过紧扎L5和L6脊神经来产生的，而L5和L6脊神经恰好位于背根神经节（DRG）的远端。手术产生神经性疼痛行为和异常的足部姿势，如前所示。另一方面，通过切除同一节段的背根和腹根，在更近的部位损伤相同的躯体感觉和运动纤维，不会产生神经性疼痛行为。背侧和腹侧根切断术的大鼠尽管没有神经性疼痛行为，但足部姿势出现异常。然而，与脊髓神经结扎大鼠相比，这些大鼠的异常程度较轻，持续时间较短。这表明，在我们的大鼠神经性疼痛模型中，周围神经损伤部分由于运动缺陷而产生足位异常。然而，异常的另一个组成部分与感觉功能有关，可能是疼痛。对数据的仔细检查表明，没有单一的明显的足部姿势异常，它完全代表运动缺陷或感觉异常。相反，神经病变的大鼠很可能由于运动和感觉异常的复杂混合而表现出异常的足部姿势。
This study was undertaken to find out whether pain contributes to abnormal posture of the foot in rats displaying neuropathic pain behaviors, and if so, whether there is a specific abnormality which reflects the level of pain. We used a rat model of neuropathic pain which is produced by tightly ligating the L5 and L6 spinal nerves just distal to the dorsal root ganglion (DRG). The operation produced neuropathic pain behaviors along with abnormal foot posture as has been shown previously. On the other hand, injury to the same somatic sensory and motor fibers at a more proximal site by sectioning dorsal and ventral roots of the same segments did not produce neuropathic pain behaviors. Rats with dorsal and ventral rhizotomies showed an abnormality of foot posture despite the absence of neuropathic pain behaviors. However, the abnormality in these rats was less severe and lasted for a shorter period of time as compared to rats with spinal nerve ligation. This suggests that peripheral nerve injury in our rat neuropathic pain model produces a foot postural abnormality partially due to motor deficit. However, there is an additional component of the abnormality that is related to sensory function, possibly pain. Close examination of the data indicate that there is no single obvious abnormal foot posture which exclusively represents motor deficit or sensory abnormality. Rather, neuropathic rats are likely to display abnormal foot posture as a result of a complex mixture of motor and sensory abnormalities.