Disorganization of retinal inner layers correlates with ellipsoid zone disruption and retinal nerve fiber layer thinning in diabetic retinopathy
Disorganization of retinal inner layers correlates with ellipsoid zone disruption and retinal nerve fiber layer thinning in diabetic retinopathy
复制标题
DOI：
10.1016/j.jdiacomp.2019.05.006
复制
发表时间：
2019-08-01
影响因子：
3
通讯作者：
Kruzliak, Peter
中科院分区：
文献类型：
--
作者：
Nadri, Gauhar;Saxena, Sandeep;Kruzliak, Peter
目的：首次应用光谱域光学相干断层扫描(SD-OCT)研究糖尿病视网膜病变(DR)患者视网膜内层(Dril)结构紊乱与黄斑厚度、椭圆形带(EZ)破裂及视网膜神经纤维层(RNFL)厚度的相关性。共纳入104例2型糖尿病患者，其中无视网膜病变的糖尿病患者26例，非增殖型糖尿病视网膜病变患者26例，增殖型糖尿病视网膜病变患者26例，正常对照组26例。最佳矫正视力(BCVA)以最小分辨角度(LogMAR)的对数表示。临床医生友好的，基于SD-OCT的分级系统是为黄斑立方体内的Dril和EZ破坏而创建的。Dril分级为：0级，Dril缺席；1级，Dril出席。脑电地形图破坏分级为：0级：完好；1级：局灶性破坏；2级：全局性破坏。结果：DRIL与DR的严重程度显著相关，Pearson相关分析显示DRIL与CST CAT呈显著正相关，与EZ破坏程度呈显著正相关。但DRIL与RNFL厚度呈显著负相关。结论：DRIL的存在与DR的严重程度、EZ断裂及RNFL变薄有关。(C)2019 Elsevier Inc.保留所有权利。
Purpose: To study the correlation between disorganization of inner retinal layer (DRIL) and macular thickness parameters, ellipsoid zone (EZ) disruption and retinal nerve fiber layer (RNFL) thickness on spectral domain optical coherence tomography (SD-OCT) in diabetic retinopathy (DR), for the first time.Methods: A tertiary care center-based cross-sectional study was undertaken. One hundred and four consecutive study subjects of type 2 diabetes mellitus were included: diabetes mellitus with no retinopathy (No DR) (n = 26); non-proliferative DR (NPDR) (n = 26); proliferative DR (PDR) (n = 26) and healthy controls (n = 26). Best Corrected Visual Acuity (BCVA) was measured on the logarithm of the minimum angle of resolution (logMAR) scale. Clinician-friendly, SD-OCT based, grading systems were created for DRIL and EZ disruption, within the macular cube. DRIL was graded as: grade 0, DRIL absent; and grade 1, DRIL present. EZ disruption was graded as; Grade 0: Intact EZ; Grade 1: Focal disruption and Grade 2: Global disruption. Every study subject underwent RNFL thickness analysis.Results: DRIL was significantly associated with increase in severity of DR.Pearson correlation analysis showed significant positive correlation between DRIL and CST CAT and grades of EZ disruption. However, a significant negative correlation was found between DRIL and RNFL thickness.Conclusion: Presence of DRIL correlates with severity of DR, EZ disruption and RNFL thinning. (C) 2019 Elsevier Inc. All rights reserved.