Acting on the call for cervical cancer elimination: Planning tools for low- and middle- income countries to increase the coverage and effectiveness of screening and treatment.
Acting on the call for cervical cancer elimination: Planning tools for low- and middle- income countries to increase the coverage and effectiveness of screening and treatment.
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DOI：
10.1186/s12913-022-08423-2
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发表时间：
2022-10-14
影响因子：
2.8
通讯作者：
de Sanjose, Silvia
中科院分区：
文献类型：
--
作者：
Herrick, Tara;Thomson, Kerry A.;Shin, Michelle;Gannon, Sarah;Tsu, Vivien;de Sanjose, Silvia
关键词：
为低收入和中等收入国家量身定制的可行的规划工具可以帮助决策者比较不同宫颈癌筛查方法的实施情况和宫颈癌高负担环境中的治疗方案。子宫颈癌前规划工具（CPPT）是由PATH开发的，供用户探索和比较筛查方法的准确性，购买什么样的治疗设备，以及如何在特定国家最好地部署治疗设备。CPPT比较了四种筛查方法：1）醋酸（VIA）目视检查，2）HPV检测，3）HPV检测后进行VIA分诊，4）HPV检测后进行增强分诊检测。筛查结果的准确性（例如，真阳性、假阳性）是基于已公布的检测宫颈癌前病变的检测灵敏度和特异性。CPPT比较了部署消融治疗设备的五种情况：1）在妇女接受筛查的每个地点配备宫颈癌前病变设备（单次就诊方法），2）仅在医院一级配备设备，3）每个地区配备一台设备，4）允许两个地区共用一台设备，5）在选定的地区医院配备设备，并配备移动的外展服务。用户可以通过调整预先填充的基线值和假设来定制CPPT，包括人口估计、筛查年龄范围、筛查频率、HPV和HIV流行率、供应成本和卫生设施细节。预防艾滋病毒/艾滋病方案编制了数据表格和图表，比较了按艾滋病毒状况分列的四种筛查和五种治疗方案的实施结果。产出包括接受筛查的妇女人数和结果、每种筛查方法的成本、通过实施HPV检测自我采样节省的提供者时间和成本、接受治疗的妇女人数、按类型划分所需的治疗设备以及每种设备部署方案的财务和经济成本。CPPT提供了实用的信息和数据，以比较患者访问和筛查准确性以及设备，技术人员和财务资源的有效利用的权衡。国家决策者可以利用预防和治疗宫颈癌方案的产出，指导扩大宫颈癌筛查和治疗的规模，同时优化有限的资源。
Accessible planning tools tailored for low-and middle-income countries can assist decision makers in comparing implementation of different cervical cancer screening approaches and treatment delivery scenarios in settings with high cervical cancer burden. The Cervical Precancer Planning Tool (CPPT) was developed by PATH for users to explore and compare the accuracy of screening approaches, what treatment equipment to procure, and how best to deploy treatment equipment in a given country. The CPPT compares four screening approaches: 1) visual inspection with acetic acid (VIA), 2) HPV testing, 3) HPV testing followed by a VIA triage, and 4) HPV testing followed by an enhanced triage test. Accuracy of screening outcomes (e.g., true positives, false positives) is based on published sensitivity and specificity of tests to detect cervical precancerous lesions. The CPPT compares five scenarios for deploying ablative treatment equipment: 1) cervical precancer equipment at every location a woman is screened (single visit approach), 2) equipment only at a hospital level, 3) a single unit of equipment in each district, 4) allowing two districts to share a single unit of equipment, and 5) equipment placed at select district hospitals paired with mobile outreach. Users can customize the CPPT by adjusting pre-populated baseline values and assumptions, including population estimates, screening age range, screening frequency, HPV and HIV prevalence, supply costs, and health facility details. The CPPT generates data tables and graphs that compare the results of implementing each of the four screening and five treatment scenarios disaggregated by HIV status. Outputs include the number and outcomes of women screened, cost of each screening approach, provider time and cost saved by implementing self-sampling for HPV testing, number of women treated, treatment equipment needed by type, and the financial and economic costs for each equipment deployment scenario. The CPPT provides practical information and data to compare tradeoffs of patient access and screening accuracy as well as efficient utilization of equipment, skilled personnel, and financial resources. Country decision makers can use outputs from the CPPT to guide the scale-up of cervical cancer screening and treatment while optimizing limited resources.
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影响因子：
3.7
作者：
Orang'o EO;Were E;Rode O;Muthoka K;Byczkowski M;Sartor H;Vanden Broeck D;Schmidt D;Reuschenbach M;von Knebel Doeberitz M;Bussmann H
通讯作者：
Bussmann H
影响因子：
4.5
作者：
Mungo C;Osongo CO;Ambaka J;Randa MA;Samba B;Ochieng CA;Barker E;Guliam A;Omoto J;Cohen CR
通讯作者：
Cohen CR
DOI：
10.1097/qad.0000000000001765
发表时间：
2018-03-27
期刊：
AIDS (London, England)
影响因子：
--
作者：
Liu G;Sharma M;Tan N;Barnabas RV
通讯作者：
Barnabas RV
影响因子：
3.2
作者：
Campos, Nicole G.;Tsu, Vivien;Kim, Jane J.
通讯作者：
Kim, Jane J.
影响因子：
3.8
作者：
Campos, Nicole G.;Sharma, Monisha;Resch, Stephen
通讯作者：
Resch, Stephen