SEASONAL-CHANGES IN PANCREATIC INSULIN AND GLUCAGON IN THE LITTLE BROWN BAT (MYOTIS-LUCIFUGUS)
SEASONAL-CHANGES IN PANCREATIC INSULIN AND GLUCAGON IN THE LITTLE BROWN BAT (MYOTIS-LUCIFUGUS)
复制标题
DOI：
10.1097/00006676-199005000-00015
复制
发表时间：
1990-05-01
期刊：
影响因子：
2.9
通讯作者：
BAUMAN, WA
中科院分区：
文献类型：
--
作者：
BAUMAN, WA
本文研究了小棕蝠(Myotis Lucifugus)胰腺胰岛素和胰升糖素的季节性变化。与10月下旬非冬眠或早期冬眠状态相比，6月份非冬眠状态的胰腺蛋白质含量增加了21%，然后在10月份和深度冬眠的月份之间下降了50%。从6月到10月，胰岛素和胰升糖素的含量增加，这两种激素在冬眠期间进一步增加，此时胰腺蛋白质含量下降。从10月到2月，胰岛素和胰高血糖素的浓度都有所上升。值得注意的是，从2月到4月，在深度冬眠期间，胰岛素浓度逐渐增加，而胰高血糖素浓度在整个时间间隔内不断上升。冬眠期间胰腺高血糖素的持续升高可能与其在空腹时的反调节和碳水化合物稳态有关。胰腺胰岛素的升高及其在冬眠期间的进一步增加尚不清楚，但可能是为了提供一个快速释放的储存池，在觉醒时立即分泌所需，可能是为了防止高渗透压状态。
Seasonal changes in pancreatic insulin and glucagon were investigated in the little brown bat (Myotis lucifugus). Pancreatic protein content increased 21% from the nonhibernating state in June compared to the nonhibernating or early hibernating state in late October, and then decreased 50% between October and the months of deep hibernation. The content of insulin and glucagon increased from June to October, and both hormones further increased during hibernation, when a fall in pancreatic protein content occurred. The concentration of both insulin and glucagon increased from October to February. Of note, the insulin concentration progressively increased during deep hibernation from February to April, whereas the glucagon concentration remianed constantly elevated throughout this time interval. The persistent elevation of pancreatic glucagon during hibernation may be related to its role in counterregulation and carbohydrate homeostasis during fasting. The elevation of pancreatic insulin, and its further increase during hibernation, is less clear but may be hypothesized to provide a rapidly releasable storage pool required for immediate secretion during arousal, possibly to prevent a hyperosmolar state.