BRIEF VISUAL EXPERIENCE INDUCES IMMEDIATE EARLY GENE-EXPRESSION IN THE CAT VISUAL-CORTEX
BRIEF VISUAL EXPERIENCE INDUCES IMMEDIATE EARLY GENE-EXPRESSION IN THE CAT VISUAL-CORTEX
复制标题
DOI：
10.1073/pnas.89.12.5437
复制
发表时间：
1992-06-15
影响因子：
11.1
通讯作者：
MOWER, GD
中科院分区：
文献类型：
--
作者：
ROSEN, KM;MCCORMACK, MA;MOWER, GD
在出生后早期发育期间，短暂的视觉体验会导致视觉皮层的快速生理变化。这些效应的一个可能的介导者是即刻早期基因，其蛋白质产物参与神经元对跨突触刺激的快速反应。在这里，我们报告的证据表明，立即早期基因mRNA在视觉皮层的水平可以通过操纵视觉环境改变。具体来说，我们发现，短暂的（1小时）在黑暗中饲养的猫的视觉体验导致戏剧性的瞬时诱导egr 1，c-fos，和junB的mRNA在视觉皮层，但不是在额叶皮层。c-jun和c-myc mRNA的水平不受影响。这些结果表明，立即早期基因蛋白的选择组合相互作用是一个重要的步骤，通过视觉引发的活动控制视觉皮层发育的级联事件。
Brief visual experience causes rapid physiological changes in the visual cortex during early postnatal development. A possible mediator of these effects is the immediate early genes whose protein products are involved in the rapid response of neurons to transsynaptic stimulation. Here we report evidence that the levels of immediate early gene mRNAs in the visual cortex can be altered by manipulating the visual environment. Specifically, we find that brief (1 h) visual experience in dark-reared cats causes dramatic transient inductions of egr1, c-fos, and junB mRNAs in the visual cortex but not in the frontal cortex. Levels of c-jun and c-myc mRNAs are unaffected. These results suggest that select combinatorial interactions of immediate early gene proteins are an important step in the cascade of events through which visually elicited activity controls visual cortical development.