Cooling an acute muscle injury: can basic scientific theory translate into the clinical setting?
Cooling an acute muscle injury: can basic scientific theory translate into the clinical setting?
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缓解急性肌肉损伤：基础科学理论可以转化为临床吗？
DOI：
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发表时间：
2011
影响因子：
18.4
通讯作者：
Michael Webb
中科院分区：
文献类型：
--
作者：
Chris M Bleakley;Phil Glasgow;Michael Webb
ICE通常用于治疗急性肌肉拉伤，但目前还没有关于其有效性的临床研究。相比之下，在动物身上进行的一些基础科学研究表明，在肌肉损伤后使用冰块对一些与恢复有关的重要细胞和生理事件具有一致的影响。其中一些影响可能是温度相关的；大多数动物研究导致损伤部位的肌肉温度显著降低。这份简短报告的目的是考虑人体肌肉损伤模型中可能出现的降温幅度，并讨论其与临床环境的相关性。目前最好的证据表明，与大多数动物模型相比，人类的肌肉温度下降是适度的，限制了直接转换到临床环境。当我们从损伤类型、深度和绝缘脂肪厚度的角度考虑肌肉损伤的异质性时，就会出现更重要的临床问题。与目前的做法相反，在临床环境中不太可能存在“灵丹妙药”的冷却剂量或持续时间。临床医生应该考虑，在肌肉拉伤的极端情况下(例如，深度损伤和损伤部位周围高水平的脂肪厚度)，降温的临床效果可能会显著降低。
Ice is commonly used after acute muscle strains but there are no clinical studies of its effectiveness. By comparison, there are a number of basic scientific studies on animals which show that applying ice after muscle injury has a consistent effect on a number of important cellular and physiological events relating to recovery. Some of these effects may be temperature dependant; most animal studies induce significant reductions in muscle temperature at the injury site. The aim of this short report was to consider the cooling magnitudes likely in human models of muscle injury and to discuss its relevance to the clinical setting. Current best evidence shows that muscle temperature reductions in humans are moderate in comparison to most animal models, limiting direct translation to the clinical setting. Further important clinical questions arise when we consider the heterogenous nature of muscle injury in terms of injury type, depth and insulating adipose thickness. Contrary to current practice, it is unlikely that a ‘panacea’ cooling dose or duration exists in the clinical setting. Clinicians should consider that in extreme circumstances of muscle strain (eg, deep injury with high levels of adipose thickness around the injury site), the clinical effectiveness of cooling may be significantly reduced.
肌肉缺血和体温过低：使用 31 磷核磁共振波谱进行的生物能研究。
DOI：
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发表时间：
1984
期刊：
The Journal of trauma
影响因子：
--
作者：
Osterman,AL;Heppenstall,RB;Sapega,AA;Katz,M;Chance,B;Sokolow,D
通讯作者：
Sokolow,D