Free radicals and disease in man.
Free radicals and disease in man.
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发表时间：
1984
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影响因子：
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通讯作者：
P. Proctor;E. Reynolds
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文献类型：
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作者：
P. Proctor;E. Reynolds
自由基和相关的活化电子物质在生物系统的抗微生物防御中，通过混合功能单加氧酶的作用，通过各种氧化酶如黄嘌呤氧化酶的作用，以及由重金属或醌类物质介导的自氧化作用产生。虽然证据是间接的，但炎症、外源性化学物质的代谢或通过自氧化产生的自由基的过度不受限制或不适当的产生可能在人类疾病中起重要作用。
Free radicals and related activated electronic species are produced in biological systems in antimicrobial defense, through the action of the mixed function monooxygenases, by various oxidative enzymes such as xanthine oxidase, and by autooxidations mediated by such agents as heavy metals or quinones. While the evidence is circumstantial, excessive unconfined or inappropriate production of radical species in inflammation, the metabolism of exogenous chemicals, or through autooxidation probably plays a significant role in human disease.