Laser Doppler flow-meter assessment of iontophoretically applied norepinephrine on human finger skin circulation.
Laser Doppler flow-meter assessment of iontophoretically applied norepinephrine on human finger skin circulation.
复制标题
激光多普勒流量计评估离子电渗疗法应用的去甲肾上腺素对人体手指皮肤循环的影响。
DOI：
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发表时间：
1986
影响因子：
6.5
通讯作者：
P. Oberg
中科院分区：
文献类型：
--
作者：
L. Lindblad;L. Ekenvall;K. Ancker;H. Rohman;P. Oberg
一种小型化的技术来管理血管活性物质离子电渗进入人的手指皮肤，并不断评估所产生的反应的血管。用激光多普勒流量计测量皮肤血流量。以去甲肾上腺素为供试品，对9名健康志愿者进行了检测。所描述的方法是以半定量的方式评价经皮施用的血管活性物质的效果的方便方式，而没有物质的中枢效应影响记录的血流的风险。
A miniaturized technique to administer vasoactive substances iontophoretically into the human finger skin and to continuously assess the resulting reaction of the vessels is described. Cutaneous blood flow is measured with a laser Doppler flow-meter. The technique has been used in 9 healthy volunteers with norepinephrine as test substance. The described method is a convenient way to evaluate the effects of transdermally applied vasoactive substances in a semiquantitative way without risking central effects of the substance to influence the registered blood flow.