The Prognostic Value of Breast Cancer Resistance Protein (BCRB/ABCG2) Expression in Breast Carcinomas
The Prognostic Value of Breast Cancer Resistance Protein (BCRB/ABCG2) Expression in Breast Carcinomas
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DOI：
10.1615/jenvironpatholtoxicoloncol.2013006767
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发表时间：
2012-01-01
影响因子：
2.4
通讯作者：
Omran, Ola M.
中科院分区：
文献类型：
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作者：
Omran, Ola M.
在癌症中，乳腺癌耐药蛋白（BCRP/ABCG 2）的表达水平可能因细胞类型而异。然而，它在乳腺癌中的确切作用一直存在争议。本研究的目的是研究乳腺癌中ABCG 2的表达，并将结果与已建立的预后因素联系起来。应用抗生物素蛋白-生物素过氧化物酶法对200例乳腺癌标本进行免疫组化研究。ABCG 2在77%的浸润性导管癌中表达。ABCG 2表达与肿瘤分级、临床分期、淋巴结转移和HER 2免疫染色均存在统计学显著相关性，但与孕激素受体（PR）和雌激素受体（ER）状态无相关性。浸润性导管癌细胞中ABCG 2表达的增加及其与HER 2表达的统计学显著相关性与人乳腺癌的肿瘤进展、浸润和转移密切相关，表明ABCG 2可用作开发新疗法的靶点。
In cancer, the level of expression of breast cancer resistance protein (BCRP/ABCG2) can vary depending on cell type. However, its precise role in breast cancer has been controversial. The aim of this study was to investigate the expression of ABCG2 in breast carcinomas and relate the results to the established prognostic factors. An immunohistochemical study was conducted on 200 breast carcinoma specimens using the avidin-biotin peroxidase method. ABCG2 was expressed in 77% of cases of invasive ductal carcinoma. There was a statistically significant correlation between ABCG2 expression and each of the tumor grade, clinical stage, lymph node metastasis, and HER2 immunostaining, but no such association with progesterone receptor (PR) and estrogen receptor (ER) status. Increased expression of ABCG2 in invasive ductal carcinoma cells and its statistically significant correlation with HER2 expression are strongly correlated with tumor progression, invasion, and metastasis in human breast cancer and indicates that ABCG2 can be used as a target for the development of novel therapies.