Calculation of population attributable risk for alcohol and breast cancer (United States)
Calculation of population attributable risk for alcohol and breast cancer (United States)
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DOI：
10.1023/a:1008853115901
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发表时间：
1999-04-01
影响因子：
2.3
通讯作者：
Longnecker, MP
中科院分区：
文献类型：
--
作者：
Tseng, M;Weinberg, CR;Longnecker, MP
目的：由于越来越多的证据表明酒精可能与乳腺癌有因果关系，我们重新考虑了美国成年女性人群中酒精和乳腺癌的人群归因风险(PAR)，使用了荟萃分析的效应估计和修正的测量误差修正的观点。方法：为了估计PAR，我们使用了一个适当的公式，与调整后的效应估计一起使用。为了估计应用该公式所需的中间量，我们使用了来自先前发表的荟萃分析的调整后的相对风险估计，以及来自第三次全国健康和营养检查调查的SEER癌症统计数据和一般人口数据。结果：酒精和乳腺癌的年龄调整后的PAR估计为2.1%。结论：由于酒精与乳腺癌之间的关联不大，而且美国女性总体上酒精摄入量适中，可归因于酒精摄入的乳腺癌比例很小。减少饮酒的广泛努力不会对这一人群的乳腺癌发病率产生实质性影响。虽然选定的女性亚群可能会从减少饮酒中受益，但这类女性的具体情况还有待定义和辩护。
Objectives: Because of increasing evidence that alcohol may be causally associated with breast cancer, we reconsider the population attributable risk (PAR) for alcohol and breast cancer for the US adult female population using an effect estimate from a meta-analysis and incorporating a revised perspective on measurement error correction.Methods: To estimate PAR, we employed a formula appropriate to use with an adjusted effect estimate. To estimate intermediate quantities needed to apply that formula, we used adjusted relative risk estimates from a previously published meta-analysis, as well as SEER cancer statistics and general population data from the third National Health and Nutrition Examination Survey. We used relative risk estimates uncorrected for measurement error.Results: The estimated age-adjusted PAR for alcohol and breast cancer was 2.1%.Conclusions: Because of the modest association between alcohol and breast cancer and the generally moderate level of alcohol intake among US women, the proportion of breast cancer attributable to alcohol intake is small. Widespread efforts to reduce alcohol consumption would not have a substantial impact on breast cancer rates in this population. While selected subgroups of women might benefit from decreasing alcohol consumption, specific profiles for such women have yet to be defined and defended.