Joint association of alcohol and folate intake with risk of major chronic disease in women
Joint association of alcohol and folate intake with risk of major chronic disease in women
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DOI：
10.1093/aje/kwg221
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发表时间：
2003-10-15
影响因子：
5
通讯作者：
Willett, WC
中科院分区：
文献类型：
--
作者：
Jiang, R;Hu, FB;Willett, WC
酒精干扰叶酸代谢，对心血管疾病和癌症的风险有相反的影响。作者研究了酒精和叶酸摄入量与主要慢性疾病风险的联合关系，定义为致命或非致命的心血管疾病或癌症，或其他非创伤性死亡。这项研究包括83，929名年龄在34-59岁之间的妇女，她们没有心血管疾病或癌症病史，并在1980年提供了饮食数据。在16年的随访中，作者记录了10，666例新的主要慢性病病例。总的来说，大量饮酒者（>30克/天）与较低的叶酸总摄入量（
Alcohol interferes with folate metabolism and has opposing effects on the risks of cardiovascular disease and cancer. The authors examined the joint association of alcohol and folate intake with risk of major chronic disease, defined as fatal or nonfatal cardiovascular disease or cancer, or other nontraumatic death. This study included 83,929 women aged 34-59 years with no previous history of cardiovascular disease or cancer who provided dietary data in 1980. During 16 years of follow-up, the authors documented 10,666 new cases of major chronic disease. Overall, heavy drinkers (>30 g/day) with a lower total folate intake (