A pilot test of a combined tobacco dependence treatment and lung cancer screening program
A pilot test of a combined tobacco dependence treatment and lung cancer screening program
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DOI：
10.1016/j.lungcan.2011.10.011
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发表时间：
2012-05-01
期刊：
影响因子：
5.3
通讯作者：
Wewers, Mary Ellen
中科院分区：
文献类型：
--
作者：
Ferketich, Amy K.;Otterson, Gregory A.;Wewers, Mary Ellen
使用计算机断层扫描进行肺癌筛查已证明死亡率显著降低。虽然这些发现对肺癌研究领域很重要，但肺癌最重要的危险因素，即吸烟，不应被忽视。我们进行了一项试点研究，以检查提供一个包括烟草依赖治疗和肺癌筛查的计划的可行性。本研究的目的是：（1）估计遵守12周治疗方案（包括烟草依赖治疗和肺癌筛查）的吸烟者比例，（2）获得4个月和6个月时戒烟和戒烟尝试的初步估计值，（3）获得认知社会健康信息处理（C-SHIP）结构的初步估计以及它们在干预后如何变化。在这项随机试点研究中，18名志愿者完成了为期12周的方案：一半在CT扫描（BCT）之前接受烟草依赖治疗计划，另一半首先接受CT扫描，然后接受治疗计划（ACT）。治疗方案包括护士提供的电话咨询和尼古丁替代疗法或伐尼克兰。只有一人没有完成所有后续评价。在入组后4个月，BCT组和ACT组的一氧化碳确认戒烟率分别为33.3%和22.2%（总体为27.8%），除1人外，所有人都尝试戒烟24小时。在6个月时，BCT组和ACT组中确认的戒烟率分别降至22.1%和11.1%（总体为16.7%），72.2%的参与者进行了24小时戒烟尝试。这些初步结果表明，在筛查测试之前提供治疗可能更好。未来需要更大样本量的随机试验来证实这些发现。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Lung cancer screening with computed tomography has demonstrated a significant reduction in mortality. While these findings are important for the lung cancer research field, the most important risk factor for lung cancer, i.e. smoking, should not be ignored. We performed a pilot study to examine the feasibility of delivering a program that included both tobacco dependence treatment and lung cancer screening. The objectives of this study were to: (1) estimate the proportion of smokers who complied with a 12-week treatment protocol that included both tobacco dependence treatment and lung cancer screening, (2) obtain preliminary estimates of abstinence and quit attempts at 4 and 6 months, and (3) obtain preliminary estimates of the cognitive social health information processing (C-SHIP) constructs and how they change following the intervention. In this randomized pilot study, 18 volunteers completed a 12-week protocol: half received the tobacco dependence treatment program before a CT scan (BCT) and the other received the CT scan first, followed by the treatment program (ACT). The treatment protocol included both nurse-delivered telephone counseling and either nicotine replacement therapy or varenicline. Only one person did not complete all follow-up evaluations. At 4 months post enrollment, the carbon monoxide confirmed quit rates were 33.3% in the BCT arm and 22.2% in the ACT arm (27.8% overall), and all but one had made a 24-h attempt to quit. At 6 months the confirmed abstinence decreased to 22.1% in the BCT arm and 11.1% in the ACT arm (16.7% overall), and 72.2% of participants had made a 24-h quit attempt. These preliminary results suggest that it might be better to deliver treatment before the screening test. Future randomized trials with a larger sample size are needed to confirm these findings. (C) 2011 Elsevier Ireland Ltd. All rights reserved.