Multiple sclerosis plaques may undergo continuous myelin degradation: a cross-sectional study with myelin and axon-related quantitative magnetic resonance imaging metrics
Multiple sclerosis plaques may undergo continuous myelin degradation: a cross-sectional study with myelin and axon-related quantitative magnetic resonance imaging metrics
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多发性硬化斑块可能会经历连续的髓磷脂降解：髓磷脂和轴突相关定量磁共振成像指标的横断面研究
DOI：
10.1007/s00234-021-02781-0
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发表时间：
2021
期刊：
影响因子：
2.8
通讯作者：
Aoki Shigeki
中科院分区：
文献类型：
--
作者：
Maekawa Tomoko;Hagiwara Akifumi;Yokoyama Kazumasa;Hori Masaaki;Andica Christina;Fujita Shohei;Kamagata Koji;Wada Akihiko;Abe Osamu;Tomizawa Yuji;Hattori Nobutaka;Aoki Shigeki
目的：我们假设髓磷脂比轴突更容易受到损伤。我们研究了从多发性硬化症（MS）斑块和髓鞘和轴突相关的定量合成磁共振成像（SyMRI）和神经突方向分散和密度成像（NODDI）metrics.MethodsWe分析了31例MS与73个新出现的斑块的估计持续时间之间的关联。进行简单线性回归分析，以评估斑块发生的估计持续时间与定量MRI指标之间的相关性。这些指标包括髓鞘体积分数（MVF）、轴突体积分数和斑块和正常白色物质中的g-比率。结果MS斑块从发病开始估计持续时间较长与较低的MVF显著相关（斜率=-0.0070，R2 = 0.0970），g-比值（斜率= 0.0078，R2 = 0.0842）较高（P均< 0.05）。SyMRI和NODDI的髓鞘成像可能有助于定量评估MS斑块的时间变化。
PurposeWe hypothesize that myelin is more susceptible to damage over time than axons. We investigated the association between the estimated duration from the onset of multiple sclerosis (MS) plaques and myelin- and axon-related quantitative synthetic magnetic resonance imaging (SyMRI) and neurite orientation dispersion and density imaging (NODDI) metrics.MethodsWe analyzed 31 patients with MS with 73 newly appeared plaques. Simple linear regression analysis was performed to assess the association between the estimated duration from the onset of plaques and quantitative MRI metrics. These metrics included the myelin volume fraction (MVF), axon volume fraction, and g-ratio in plaque and normal-appearing white matter.ResultsMS plaques with a longer estimated duration from onset were significantly correlated with a lower MVF (slope = − 0.0070,R2= 0.0970), higher g-ratio (slope = 0.0078,R2= 0.0842) (allPvalues < 0.05).ConclusionThese results suggested that myelin in plaques undergoes continuous damage, more so than axons. Myelin imaging with SyMRI and NODDI may be useful for the quantitative assessment of temporal changes in MS plaques.