Increased risks of healthcare-seeking behaviors of anxiety, depression and insomnia among patients with bladder pain syndrome/interstitial cystitis: a nationwide population-based study
Increased risks of healthcare-seeking behaviors of anxiety, depression and insomnia among patients with bladder pain syndrome/interstitial cystitis: a nationwide population-based study
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DOI：
10.1007/s11255-014-0908-6
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发表时间：
2015-02-01
影响因子：
2
通讯作者：
Wu, Ming-Ping
中科院分区：
文献类型：
--
作者：
Chuang, Yao-Chi;Weng, Shih-Feng;Wu, Ming-Ping
目的探讨膀胱疼痛综合征/间质性膀胱炎（BPS/IC）与台湾常见精神障碍患者后续求医行为风险的关系。从2002年到2010年，从招募日期开始，精神科医生为BPS/IC受试者和他们年龄和性别匹配的非BPS/IC对照受试者提供了这些精神障碍的服务，这些受试者之前没有失眠和精神疾病，包括焦虑、抑郁。采用Kaplan-Meier曲线评估结局风险；采用泊松回归分析和Cox比例风险模型估计BPS/IC的影响。我们纳入了16,185名BPS/IC受试者和32,370名非BPS/IC受试者，平均年龄46岁，73.5%为女性。高血压、糖尿病、慢性肾病、高脂血症患病率组间差异无统计学意义。BPS/IC患者的焦虑、抑郁和失眠发生率显著高于对照组（每万人年92.9 vs 38.4, 101.0 vs 42.2, 47.5 vs 23.0）。在多变量分析中调整了年龄、性别和常见合共病后，BPS/IC仍然是一个显著的预测因子，焦虑、抑郁和失眠的风险比和95%置信度分别为2.4（2.2-2.7）、2.4（2.2-2.6）和2.1（1.8-2.4）。BPS/IC患者有发展为焦虑、抑郁和失眠的风险。这些发现有助于指导泌尿科医生、泌尿妇科医生和精神科医生早期识别和治疗BPS/IC患者可能出现的心理并发症。
To explore the association between bladder pain syndrome/interstitial cystitis (BPS/IC) and the risk of subsequent healthcare-seeking behavior for common mental disorders in Taiwan using a population-based administrative database.Both BPS/IC subjects and their age- and sex-matched non-BPS/IC control subjects who had no previous insomnia and mental diseases, including anxiety, depression, were subsequent serviced for these mental disorders by psychiatrists from the recruited date between 2002 and 2010. The risk of outcomes was assessed with Kaplan-Meier curves; and the impact of BPS/IC was estimated with Poisson regression analysis and Cox proportional hazards models.We included 16,185 BPS/IC subjects and 32,370 non-BPS/IC subjects, with a mean age of 46 years and 73.5 % of women. Difference of the prevalence of hypertension, diabetes, chronic kidney disease, and hyperlipidemia between groups was not significant difference. Subjects with BPS/IC had a significant higher incidence rate of anxiety, depression, and insomnia than the matched controls (92.9 vs 38.4, 101.0 vs 42.2, 47.5 vs 23.0; per 10,000 person-year). After adjusting for age, sex, and common comorbidities in multivariable analysis, BPS/IC remained a significant predictor with hazard ratio and 95 % confidence incidence, 2.4 (2.2-2.7), 2.4 (2.2-2.6), and 2.1 (1.8-2.4) for anxiety, depression, and insomnia, respectively.Patients with BPS/IC are at risk of development of anxiety, depression, and insomnia. These findings can help guide urologists, urogynecologists, and psychiatrists toward early identification and treatment of psychological complications that may develop in BPS/IC patients.