The Effects of N,N-Diethyl-4-Methyl-3-Oxo-4-Aza-5α-Androstane-17yβ-Carboxamide, a 5α-Reductase Inhibitor and Antiandrogen, on the Development of Baldness in the Stumptail Macaque
The Effects of N,N-Diethyl-4-Methyl-3-Oxo-4-Aza-5α-Androstane-17yβ-Carboxamide, a 5α-Reductase Inhibitor and Antiandrogen, on the Development of Baldness in the Stumptail Macaque
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N,N-二乙基-4-甲基-3-Oxo-4-Aza-5α-Androstane-17yβ-Carboxamide（5α-还原酶抑制剂和抗雄激素）对短尾猴秃发发展的影响
DOI：
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
D. Loriaux
中科院分区：
文献类型：
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作者：
R. Rittmaster;H. Uno;M. Povar;T. Mellin;D. Loriaux
我们使用雄性型秃发的灵长类动物模型来测试局部应用5α-还原酶抑制剂和抗雄激素（4-MA）预防秃发的功效。6只青春期短尾猴每天局部应用4-MA二甲亚砜或二甲亚砜单独给药27个月。三只对照猴出现不同程度的秃顶，而三只4-MA处理猴保留其幼年毛发生长模式。4-MA处理组中额部头皮中活跃生长的毛囊的百分比没有改变[46 ± 6（±se）vs. 48 ± 4]，而对照组中显著降低（63 ± 6 vs. 25 ± 12; P < 0.025）。4-MA处理猴头皮中的皮肤5α-还原酶活性降低。我们的结论是，局部4-MA可以防止秃发在短尾猕猴，雄激素依赖性秃发的灵长类动物模型的发展。
We used a primate model of male-pattern baldness to test the efficacy of a topically applied 5α-reductase inhibitor and antiandrogen (4-MA) in the prevention of baldness. Six periadolescent stumptail macaques were given daily topical applications of either 4-MA in dimethylsulfoxide or dimethylsulfoxide alone for 27 months. The three control monkeys developed varying degrees of baldness, while the three 4-MA-treated monkeys retained their juvenile pattern of hair growth. The percentage of actively growing hair follicles in the frontal scalp did not change in the 4-MA-treated group [46 ± 6 (±se) vs. 48 ± 4], while a significant decrease occurred in the control group (63 ± 6 vs. 25 ± 12; P < 0.025). Skin 5α-reductase activity was reduced in the scalp of the 4-MA-treated monkeys. We conclude that topical 4-MA can prevent the development of baldness in the stumptail macaque, a primate model of androgendependent baldness.
外周组织事件在多囊卵巢综合征多毛症发展中重要性的证据。
DOI：
10.1210/jcem-57-2-393
发表时间：
1983
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
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作者：
Lobo,RA;Goebelsmann,U;Horton,R
通讯作者：
Horton,R