An epidemic of pneumococcus bronchopneumonia
An epidemic of pneumococcus bronchopneumonia
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DOI：
10.1093/infdis/24.6.594
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发表时间：
1919-01-01
影响因子：
6.4
通讯作者：
McKinney, M
中科院分区：
文献类型：
--
作者：
Hirsch, EF;McKinney, M
一种不寻常的毒力流行病在9月19日至19日期间迅速席卷了格兰特营的几个组织。1918年10月21日和1918年10月18日（大约）。在此期间，基地医院收治了9，037名病人，约占营地人数的四分之一，其中26%患上了肺炎。约占总入院人数的11%，或总肺炎患者的43%。从早期入院患者的咽部培养中，肺炎球菌的恢复具有显著的稳定性，流感杆菌的发现异常。对流行病期间死亡的病人进行的尸检显示，有规律地出现大面积支气管扩张症。在患病的肺、心脏血液、渗出物、液体和身体的其他患病病灶的培养物中，肺炎球菌是主要的生物体。90例流行性肺炎住院患者血培养阳性率为50%，仅检出肺炎双球菌。从头部、中耳、结膜和脓胸渗出液的感染窦中回收纯培养的肺炎球菌。用流行期间分离的肺炎球菌接种动物，证明这些生物体具有高毒力。对逃离流行病的集中营囚犯进行的对照咽喉培养几乎不含致病微生物。
An epidemic of unusual virulence swept with great rapidity through several organizations in Camp Grant between Sept. 21, 1918, and Oct. 18, 1918 (approximately). During this time 9,037 patients were admitted to the base hospital, representing about one-fourth the strength of the camp, and of them, 26% developed pneumonia. About 11% of the total admissions, or 43% of the total pneumonia patients died. From the throat cultures of the early admissions pneumococci were recovered with remarkable constancy, influenza bacilli were f ound exceptionally. Postmortem examination of patients dying during the epidemic demonstrated regularly a massive bronchopneumonia. In cultures of the diseased lungs, heart blood, exudates, fluids, and other diseased foci of the body, pneumococci were the predominating organisms. Blood cultures of 90 patients in the hospital with pneumonia of the epidemic disease were positive in 50%, pneumococci being the only organisms recovered. Pneumococci in pure cultures were recovered from infected sinuses o f the head, the middle ear, conjunctival and empyema exudates. Inoculation of animals with pneumococci isolated during the epidemic demonstrated a high virulence of these organisms. Control throat cultures made of prisoners in the camp escaping the epidemic disease contained practically no pathogenic organisms.