Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2
Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2
复制标题
DOI：
10.1016/j.febslet.2004.05.075
复制
发表时间：
2004-07-02
期刊：
影响因子：
3.5
通讯作者：
Petit, MMR
中科院分区：
文献类型：
--
作者：
Brants, JR;Ayoubi, TAY;Petit, MMR
高迁移率组A2 （HMGA2）是一种受发育调控的建筑转录因子，参与生长调控，在胚胎发生和肿瘤发生中发挥重要作用。然而，人们对其下游目标知之甚少。与野生型小鼠相比，我们在两种hmga2缺陷小鼠品系中寻找在胚胎发育过程中表达强烈改变的基因，这些品系表现出侏儒表型。我们发现在突变体E12.5胚胎中，胰岛素样生长因子II mrna结合蛋白2基因（IMP2），而不是其家族成员IMP1和IMP3，明显下调。此外，我们发现野生型HMGA2及其肿瘤特异性截断形式对IMP2表达具有相反的影响。我们的研究结果清楚地表明，HMGA2在胚胎发生过程中对IMP家族成员的表达有差异调节。(C) 2004年由Elsevier B.V.代表欧洲生化学会联合会出版。
The developmentally regulated architectural transcription factor, high mobility group A2 (HMGA2), is involved in growth regulation and plays an important role in embryogenesis and tumorigenesis. Little is known, however, about its downstream targets. We performed a search for genes of which expression is strongly altered during embryonic development in two HMGA2-deficient mouse strains, which display a pygmy-phenotype, as compared to wild-type mice. We found that the insulin-like growth factor II mRNA-binding protein 2 gene (IMP2), but not its family members IMP1 and IMP3, was robustly downregulated in mutant E12.5 embryos. Furthermore, we show that wild-type HMGA2 and its tumor-specific truncated form have opposite effects on IMP2 expression. Our results clearly indicate that HMGA2 differentially regulates expression of IMP family members during embryogenesis. (C) 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.