THE REPRESENTATION OF THE AUDITORY AND SOMATOSENSORY SYSTEMS IN THE EXTERNAL NUCLEUS OF THE CAT INFERIOR COLLICULUS
THE REPRESENTATION OF THE AUDITORY AND SOMATOSENSORY SYSTEMS IN THE EXTERNAL NUCLEUS OF THE CAT INFERIOR COLLICULUS
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DOI：
10.1002/cne.901960104
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发表时间：
1981-01-01
影响因子：
2.5
通讯作者：
PHILPOTT, P
中科院分区：
文献类型：
--
作者：
AITKIN, LM;KENYON, CE;PHILPOTT, P
在麻醉猫上进行了平行单单位和逆行追踪实验，以阐明听觉和躯体感觉系统在下丘外核（ICX）的代表性。在ICX和邻近的丘间区（伊卡）中，对音调刺激做出反应的单位比具有确定的触觉感受野的单位更常见。大量的逆行标记的细胞被确定在中脑听觉结构，注射辣根过氧化物酶（HRP）到ICX后，比在联合背柱核。微电极记录显示，ICX代表了整个可及体表，单个单位的感受野通常较大，且大多位于对侧。HRP标记细胞散在分布于对侧楔束核、薄束核和三叉神经脊束核。通常观察到对复杂声音的反应。双耳刺激影响了大多数听觉单位的放电。注射ICX后，标记的听觉神经元主要位于两侧的下丘。示踪剂扩散到中央和中央周围核与标记的许多神经元在后脑听觉结构。在电生理实验中，只观察到模糊的建议，somatotopy或tonotopy;同样，HRP注射部位和逆行标记位点在一个给定的突出核之间没有地形关系可以辨别。根据ICX中的双重会聚感觉表征，对该结构在声运动机制中的作用进行了推测。
Parallel single unit and retrograde tracing experiments were carried out in the anesthetized cat to elucidate the representation of the auditory and somatosensory systems in the external nucleus of the inferior colliculus (ICX). Units responding to tonal stimuli were more commonly encountered in ICX and the adjacent intercollicular area (ICA) than were units with identified tactile receptive fields. A larger number of retrogradely labeled cells were identified in midbrain auditory structures, following injections of horseradish peroxidase (HRP) into ICX, than were in the combined dorsal column nuclei. Microelectrode recording revealed that the entire accessible body surface was represented in ICX, and receptive fields of individual units were usually large and mostly located on the contralateral side. HRP-labeled cells were scattered throughout the contralateral cuneate, gracile and spinal trigeminal nuclei. Responses to complex sound were commonly observed. Binaural stimuli influenced the firing of the majority of auditory units. Labeled auditory neurons following ICX injections were found mainly in the inferior colliculus of both sides. Spread of tracer into the central and pericentral nuclei was associated with labeling of many neurons in hindbrain auditory structures. Only vague suggestions of somatotopy or tonotopy were observed in the electrophysiological experiments; similarly, no topographical relationship between HRP injection site and locus of retrograde label in a given projecting nucleus could be discerned. Speculations were made, in the light of the dual convergent sensory representation in ICX, about the role of this structure in acoustico-motor mechanisms.