Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice
Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice
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DOI：
10.1271/bbb.65.2735
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发表时间：
2001-12-01
影响因子：
1.6
通讯作者：
Fushiki, T
中科院分区：
文献类型：
--
作者：
Ohnuki, K;Haramizu, S;Fushiki, T
我们研究了单次口服辣椒酸酯的作用，辣椒酸酯存在于一种不辛辣的辣椒品种CH-19 Sweet的果实中，除了烷基链上的氢被O取代之外，它与辣椒素具有相同的结构，在小鼠体内具有产热作用和脂肪积累。辣椒素（10 mg/kg-体重）组和辣椒素（10 mg/kg-体重）组的耗氧量和血清肾上腺素浓度均高于对照组。我们还研究了2周的辣椒素和辣椒素对体脂肪积累的影响。每天服用辣椒素（10、50 mg/kg-体重/天）可显著抑制体脂肪积累和辣椒素（10 mg/kg-体重/天）。这些结果表明，与辣椒素一样，辣椒素也能促进能量代谢，抑制体内脂肪堆积。
We investigated the effects of a single oral administration of capsiate, which is found in the fruits of a non-pungent cultivar of pepper, CH-19 Sweet, and has the same structure as capsaicin except for replacement of NH by O in the alkyl chain, oil the thermogenesis and fat accumulation in mice. The oxygen consumption and serum adrenalin concentration were higher in both the capsaicin (10 mg/kg-body weight) and capsiate (10 mg/kg-body weight) groups than those in the control group. We also examined the effects of 2 weeks of administration of capsaicin and capsiate on body fat accumulation. Eevery day for 2 weeks administration of capsiate (10, 50 mg/kg-body weight/day) markedly suppressed body fat accumulation as well as capsaicin (10 mg/kg-body weight/day). These results suggest that capsiate promotes energy metabolism and suppresses body fat accumulation as does capsaicin.