Delayed gadolinium-enhanced magnetic resonance imaging of the meniscus - An index of meniscal tissue degeneration?
Delayed gadolinium-enhanced magnetic resonance imaging of the meniscus - An index of meniscal tissue degeneration?
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DOI：
10.1002/art.22592
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发表时间：
2007-05-01
影响因子：
--
通讯作者：
Burstein, Deborah
中科院分区：
文献类型：
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作者：
Krishnan, Nitya;Shetty, Sanjay K.;Burstein, Deborah
Objective.近年来，人们越来越关注如何更好地了解膝关节骨关节炎（OA）的发病机制和自然进展，尤其是在其早期阶段。一种用于研究早期OA的技术是软骨的延迟钆增强磁共振成像（dGEMRIC），其中T1（Gd）（MRI造影剂钆喷酸葡胺[Gd-DTPA（2-）]渗透后的T1值）用作关节软骨分子状态的指标。本研究的目的是探讨半月板的T1（Gd）及其与关节软骨T1（Gd）的关系，在膝盖dGEMRIC图像数据集。对21例无症状受试者和9例自报OA患者的膝关节dGEMRIC进行研究，并根据膝关节dGEMRIC图像制作半月板和关节软骨的T1（Gd）图。半月板的TI（Gd）涵盖了一系列数值（247-515 msec）和模式（均匀和局灶性变化）。此外，半月板和关节软骨的TI（Gd）具有相关性内侧后半月板与股骨内侧和胫骨内侧软骨的相关性分别为R = 0.38，P = 0.037; R = 0.57，P = 0.001;前半月板和外侧间室的TI [Gd]也相关，R > 0.38和P < 0.037），可能表明膝关节的平行降解过程。虽然TI（Gd）结果相对于半月板分子结构的生物物理基础需要调查，这些发现引入了一个潜在的手段，检查关节炎的发展和进展中的关节组织变化的时间过程。
Objective. Much attention has been focused recently on the need for a better understanding of the mechanisms and natural progression of knee osteoarthritis (OA), particularly in its early stages. One technique that has been used to investigate early OA is delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC), where T1 (Gd) (T1 value after penetration of the MRI contrast agent gadopentate dimeglumine [Gd-DTPA(2-)]) is used as an index of the molecular status of articular cartilage. The goal of this study was to explore T1(Gd) in the meniscus and its relationship with articular cartilage T1(Gd) in knee dGEMRIC image data sets.Methods. T1(Gd) maps of the meniscus and articular cartilage were made from knee dGEMRIC images obtained from prior studies of dGEMRIC of the knee in 21 asymptomatic subjects and 9 patients with self-reported OA.Results. TI(Gd) of the meniscus covered a range of values (247-515 msec) and patterns (homogeneous and focal variations). In addition, TI(Gd) of the meniscus correlated with that of articular cartilage (R = 0.38, P = 0.037; R = 0.57, P = 0.001 for correlations of the medial posterior meniscus with the medial femoral and tibial cartilage, respectively; TI [Gd] of the anterior meniscus and lateral compartments also correlated, with R > 0.38 and P < 0.037), potentially demonstrating parallel degradative processes in the knee.Conclusion. While the biophysical basis for the TI(Gd) results relative to meniscus molecular structure needs investigation, these findings introduce a potential means of examining the time course of meniscal tissue change in the development and progression of arthritis.