The Biology of Long-Term Denervated Skeletal Muscle.
The Biology of Long-Term Denervated Skeletal Muscle.
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DOI：
10.4081/ejtm.2014.3293
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发表时间：
2014-03-31
影响因子：
2.2
通讯作者：
Carlson BM
中科院分区：
文献类型：
--
作者：
Carlson BM
这篇评论集中在生物学的长期失神经肌肉，特别是因为它涉及到更新的技术，恢复功能质量。失神经支配后，肌肉经历三个阶段：1）立即丧失随意功能和质量迅速损失，2）肌节组织的萎缩和损失增加，以及3）肌纤维变性和纤维结缔组织和脂肪替代肌肉。与萎缩和退化的总体程序并行的是卫星细胞的增殖和激活，以及失神经肌肉内新肌生成的出现。诸如功能性电刺激的技术利用这种能力来恢复失神经肌肉的功能质量。
This review concentrates on the biology of long-term denervated muscle, especially as it relates to newer techniques for restoring functional mass. After denervation, muscle passes through three stages: 1) immediate loss of voluntary function and rapid loss of mass, 2) increasing atrophy and loss of sarcomeric organization, and 3) muscle fiber degeneration and replacement of muscle by fibrous connective tissue and fat. Parallel to the overall program of atrophy and degeneration is the proliferation and activation of satellite cells, and the appearance of neomyogenesis within the denervated muscle. Techniques such as functional electrical stimulation take advantage of this capability to restore functional mass to a denervated muscle.