Comparison of serology and reactogenicity between influenza subunit vaccines and whole virus or split vaccines - A review and meta-analysis of the literature
Comparison of serology and reactogenicity between influenza subunit vaccines and whole virus or split vaccines - A review and meta-analysis of the literature
复制标题
DOI：
10.2165/00044011-199815010-00001
复制
发表时间：
1998-01-01
影响因子：
3.2
通讯作者：
Osterhaus, ADME
中科院分区：
文献类型：
--
作者：
Beyer, WEP;Palache, AM;Osterhaus, ADME
目前有三种不同的灭活流感疫苗类型：全病毒（WV），裂解（SPL）和亚单位（SU）疫苗。有流感并发症风险的医生和患者可能想知道，在抗体诱导（血清学）、酸性不良反应（反应原性）方面，疫苗类型之间是否存在重要差异。进行了文献综述（1975年至1995年），以评价SU疫苗与裂解或全病毒疫苗相比的血清学和反应原性。确定了22篇随机分配的出版物，共描述了5416个血清学观察结果、2858个局部反应观察结果和2990个全身反应观察结果。受试者包括从儿童到老年人的所有年龄组。计算SU与SPL或SU与WV疫苗比较的绝对保护和反应率差异（RD）。对这些数据进行荟萃分析，得出合并率差异及其95%置信区间。除了在1957年以后出生且未暴露于1977年后重新出现的H1N1亚型的受试者中比较SU与WV疫苗外，未发现证据表明目前可用的三种灭活流感疫苗类型之间的血清应答存在相关差异。虽然在荟萃分析中，关于儿童疫苗的数据不足，但对于这些疫苗存在具体建议，接种三种疫苗类型中的任何一种后的不良事件通常是轻度和短暂的;然而，SU疫苗与局部和全身反应的频率较低相关。
Currently three different inactivated influenza vaccine types are available: whole virus (WV), split (SPL) and subunit (SU) vaccines. Physicians and patients at risk for influenza complications may wonder whether there are important differences between the vaccine types with respect to antibody induction (serology) acid adverse effects (reactogenicity). A literature review (1975 to 1995) was performed to evaluate the serology and reactogenicity of SU vaccines in comparison with either split or whole virus vaccines. 22 publications with randomised allocation were identified describing a total of 5416 serological observations, 2858 observations of local reactions, and 2990 observations of systemic reactions. Subjects included those from all age groups from children to the elderly. Absolute protection and reaction rate differences (RD) were calculated for the comparisons SU vs SPL or SU vs WV vaccine. These were subjected to a method of metaanalysis, resulting in pooled rate differences and their 95% confidence intervals. With the exception of the comparison SU vs WV vaccine in subjects born after 1957 and unexposed to the reappearing H1N1 subtype after 1977, no evidence was found to suggest relevant differences in seroresponse among the three currently available inactivated influenza vaccine types. Although insufficient data were available in the meta-analysis for vaccines in children for whom specific recommendations concerning these vaccines exist, adverse events after administration of any of the three vaccine types were generally mild and transitory; however, SU vaccines were associated with a lower frequency of local and systemic reactions.