IMMUNIZATION WITH ASIAN-STRAIN INFLUENZA VACCINE - EQUIVALENCE OF THE SUBCUTANEOUS AND INTRADERMAL ROUTES
IMMUNIZATION WITH ASIAN-STRAIN INFLUENZA VACCINE - EQUIVALENCE OF THE SUBCUTANEOUS AND INTRADERMAL ROUTES
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DOI：
10.1056/nejm195809252591304
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发表时间：
1958-01-01
影响因子：
158.5
通讯作者：
KILBOURNE, ED
中科院分区：
文献类型：
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作者：
MCCARROLL, JR;KILBOURNE, ED
362名未经选择的医院员工按6种不同的注射程序注射甲型流感疫苗，不同的抗原剂量和给药途径不同。在本研究中，抗体应答的发生是次佳的，最大剂量为200个CCA单位。然而，重要的发现来自于这项研究，它使用了小的抗原团的边缘功效。将疫苗分成两次注射，相隔7天，所产生的反应优于相同总剂量的单次注射。皮下注射的小剂量至少与皮内注射的等量剂量的抗原性效果相同。
Three hundred sixty-two unselected hospital employees were injected with influenza A vaccine by 6 different schedules in which antigen dosage and route of administration were varied. The occurrence of antibody response was suboptimal in this study, in which the maximum dose was 200 CCA units. However, important findings derived from the study, which employed small antigenic mass of borderline efficacy. Division of vaccine into 2 injections given 7 days apart induced a response superior to that effected by the same total dose in a single injection. Small doses by the subcutaneous route were at least equivalent in antigenic efficacy to equivalent doses administered intradermally.