Inflammatory response to implants.
Inflammatory response to implants.
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DOI：
10.1097/00002480-198804000-00005
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发表时间：
1988-04-01
期刊：
影响因子：
--
通讯作者：
Anderson, J M
中科院分区：
文献类型：
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作者：
Anderson, J M
人工器官、医疗器械或生物材料的植入会造成损伤并引发炎症反应。这种对植入物的炎症反应包括急性炎症、慢性炎症、与肉芽组织的异物反应以及巨噬细胞与异物巨细胞的相互作用。人工器官、医疗器械、假体或生物材料表面的形状和地形可以决定异物反应的组成。正常的异物反应包括植入物表面的巨噬细胞和异物巨细胞，并伴有下周成纤维细胞增殖和胶原沉积，毛细血管形成。巨噬细胞在组织对植入物的反应中起着关键作用。关于补体活化和补体介导的细胞粘附到植入体表面的作用的假设已经提出。巨噬细胞粘附和随后的激活导致细胞介质和细胞间的通信被描述。
The implantation of artificial organs, medical devices, or biomaterials results in injury and initiation of the inflammatory response. This inflammatory response to implants has as its components acute inflammation, chronic inflammation, foreign body reaction with granulation tissue, and macrophage and foreign body giant cell interactions. The form and topography of the surface of the artificial organ, medical device, prosthesis, or biomaterial can determine the composition of the foreign body reaction. The normal foreign body reaction consists of macrophages and foreign body giant cells at the surface of the implant with subjacent fibroblastic proliferation and collagen deposition, and capillary formation. Macrophages play a pivotal role in the response of tissue to implants. An hypothesis on the role of complement activation and complement-mediated cellular adhesion to implant surfaces has been presented. Macrophage adhesion and subsequent activation leading to cell-mediator and cell-cell communication is described.