Dengue virus infection induces expansion of a CD14(+)CD16(+) monocyte population that stimulates plasmablast differentiation.
Dengue virus infection induces expansion of a CD14(+)CD16(+) monocyte population that stimulates plasmablast differentiation.
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登革热病毒感染诱导CD14（+）CD16（+）单核细胞种群的扩展，从而刺激了浆膜分化。
DOI：
10.1016/j.chom.2014.06.001
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发表时间：
2014-07-09
影响因子：
30.3
通讯作者：
Pulendran B
中科院分区：
文献类型：
--
作者：
Kwissa M;Nakaya HI;Onlamoon N;Wrammert J;Villinger F;Perng GC;Yoksan S;Pattanapanyasat K;Chokephaibulkit K;Ahmed R;Pulendran B
Dengue virus (DENV) infection induces the expansion of plasmablasts, which produce antibodies that can neutralize DENV but also enhance disease upon secondary infection with another DENV serotype. To understand how these immune responses are generated, we used a systems biological approach to analyse immune responses to dengue in humans. Transcriptomic analysis of whole blood revealed that genes encoding pro-inflammatory mediators and type I IFN-related proteins were associated with high DENV levels during initial symptomatic disease. Additionally, CD14+CD16+ monocytes increased in the blood. Similarly, in a non-human primate model, DENV infection boosted CD14+CD16+ monocyte numbers in the blood and lymph nodes. Upon DENV infection in vitro, monocytes up-regulated CD16 and mediated differentiation of resting B cells to plasmablasts as well as IgG and IgM secretion. These findings provide a detailed picture of innate responses to dengue and highlight a role for CD14+CD16+ monocytes in promoting plasmablast differentiation and anti-DENV antibody responses.
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影响因子：
30.3
作者：
Beltramello M;Williams KL;Simmons CP;Macagno A;Simonelli L;Quyen NT;Sukupolvi-Petty S;Navarro-Sanchez E;Young PR;de Silva AM;Rey FA;Varani L;Whitehead SS;Diamond MS;Harris E;Lanzavecchia A;Sallusto F
通讯作者：
Sallusto F
影响因子：
5.4
作者：
Bosch, I;Xhaja, K;Rothman, AL
通讯作者：
Rothman, AL
影响因子：
5.4
作者：
Boonnak, Kobporn;Slike, Bonnie M.;Marovich, Mary A.
通讯作者：
Marovich, Mary A.
DOI：
10.4269/ajtmh.1988.38.172
发表时间：
1988-01-01
影响因子：
3.3
作者：
BURKE, DS;NISALAK, A;SCOTT, RM
通讯作者：
SCOTT, RM
影响因子：
16.8
作者：
Ingersoll MA;Platt AM;Potteaux S;Randolph GJ
通讯作者：
Randolph GJ