Efficient stabilization of natural curcuminoids mediated by oil body encapsulation
Efficient stabilization of natural curcuminoids mediated by oil body encapsulation
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DOI：
10.1039/c3ra40552d
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发表时间：
2013-01-01
期刊：
影响因子：
3.9
通讯作者：
Santino, Angelo
中科院分区：
文献类型：
--
作者：
Bettini, Simona;Vergara, Daniele;Santino, Angelo
姜黄素是一种天然的疏水性多酚，存在于姜黄的根茎粉末中。由于其干扰许多信号通路的能力，已经表明姜黄素具有潜在的有益药理作用，包括抗氧化剂，抗炎，抗癌特性。然而，姜黄素的使用是相当有限的，因为它的水溶性差，生物利用度低，在碱性pH值的组织吸收和降解不足。在目前的贡献，我们首先验证了天然姜黄素对两种不同的细胞系来自卵巢癌和乳腺癌的抗增殖作用。后来，姜黄素类化合物被成功地包封到重构的油体中。一旦包封到重构油体的三酰甘油核心中，姜黄素（三种姜黄素类中最疏水和活性的）与白蛋白稳定化相比更好地稳定化。油体包封的姜黄素类化合物显示出与游离药物相同的对癌细胞活力的影响，证实了天然油体作为微/纳米胶囊在药物递送应用中的巨大潜力。
Curcumin is a natural hydrophobic polyphenol found in the powdered rhizomes of Curcuma longa. Due to its capacity to interfere with many signalling pathways, it has been shown that curcumin has potential beneficial pharmacological effects including antioxidant, anti-inflammatory, anticarcinogenic properties. However, the use of curcumin is fairly restricted because of its poor water solubility, low bioavailability, inadequate tissue absorption and degradation at alkaline pH. In the present contribution, we first verified the anti-proliferative effects of natural curcuminoids towards two different cell lines derived from an ovarian and a breast adenocarcinoma cancer. Later, curcuminoids were successfully encapsulated into reconstituted oil bodies. Once encapsulated into the triacylglycerol cores of the reconstituted oil bodies, curcumin, the most hydrophobic and active of the three curcuminoids, was better stabilized in comparison with albumin stabilization. Oil body encapsulated curcuminoids showed the same effects on cancer cell viability as the free drug, confirming the great potential of natural oil bodies as micro/nano-capsules in drug delivery applications.