Morphology and chronology of diphyodont dentition in miniature pigs, Sus Scrofa
Morphology and chronology of diphyodont dentition in miniature pigs, Sus Scrofa
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DOI：
10.1111/odi.12126
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发表时间：
2014-05-01
期刊：
影响因子：
3.8
通讯作者：
Wang, S.
中科院分区：
文献类型：
--
作者：
Wang, F.;Xiao, J.;Wang, S.
关于大型哺乳动物牙齿替换的知识很少。本研究的目的是探讨牙齿替换模式在中国小型猪（Sus Scrofa）.Materials and MethodsThe发育模式的下颌骨继承和额外的牙齿从中国小型猪出生前后进行了调查，显微解剖，免疫组织化学，和锥形束CT.ResultsSecondary dental lamina为继承牙齿是不可见的，直到它的前身进展到晚钟阶段。当它们的前身开始爆发时，继承牙齿达到早期帽状阶段。前、后牙接续牙的发育方式和速度各不相同。附加磨牙起源于附加牙板的游离端，在下颌升支中依次发生，而先前的附加磨牙则进展到钟状晚期。永久原基中的增殖细胞分布不对称。ConclusionsOur的研究结果确定了其前身和级联启动额外的小型猪磨牙的上下文中的继承性牙齿的时空形态发生的特征模式。我们的研究为进一步了解人类双牙替换的机制提供了基础，也为大型动物的牙齿再生和牙齿工程提供了帮助。
ObjectiveThere is little knowledge about the tooth replacement in large mammals. The aim of this study is to investigate the tooth replacement patterns in Chinese miniature pig (Sus Scrofa).Materials and MethodsThe developmental patterns of mandibular successional and additional teeth from Chinese miniature pig before and after birth were investigated by microanatomy, immunohistochemistry, and cone beam computed tomography.ResultsSecondary dental lamina for successional teeth was not visible until its predecessor progressed to late bell stage. Successional teeth reached early cap stage when their predecessor began to erupt. The development patterns and speed varied between anterior and posterior successional teeth. Additional molars, derived from the free end of additional dental lamina, initiated sequentially in mandible ramus, while previous additional molar progressed into late bell stage. Proliferating cells in the permanent primordium were distributed asymmetrically.ConclusionsOur findings identify the characteristic patterns about spatiotemporal morphogenesis of successional teeth in context of their predecessor and cascade initiation of additional molars in miniature pigs. Our study provides a basis toward better understanding the mechanisms underlying diphyodont replacement in human and also assists in tooth regeneration and tooth engineering in large animal.