Characterization of select members of the Taxane family using Raman spectroscopy
Characterization of select members of the Taxane family using Raman spectroscopy
复制标题
使用拉曼光谱表征紫杉烷家族的选定成员
DOI：
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
D. Ben‐Amotz
中科院分区：
文献类型：
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作者：
P. Cipriani;D. Ben‐Amotz
实验导出的拉曼光谱的三个成员的紫杉烷家族的介绍和讨论。所研究的紫杉烷是多西他赛（Taxotere®）、巴卡亭III和三尖杉碱。这些分析物的研究，因为他们的强大的抗肿瘤能力，或者他们是潜在的前体，用于合成高价值的药物。滴涂沉积拉曼（DCDR）光谱用于检查粉末和溶液的振动波数，浓度低至1 µM。通过与相关文献和量子力学从头计算的比较，证实了其中两种紫杉烷的正常拉曼模式。版权所有© 2005年约翰威利父子有限公司。
Experimentally derived Raman spectra of three members of the taxane family are presented and discussed. The taxoids investigated were docetaxel (Taxotere® ), baccatin III and cephalotaxine. These analytes were studied because of their potent antitumor capability or they are potential precursors for the synthesis of highly valuable pharmaceutical drugs. Drop coating deposition Raman (DCDR) spectroscopy is utilized in order to examine the vibrational wavenumbers of the powders and solutions, down to concentrations as low as 1 µM. Normal Raman modes of two of the three taxanes are confirmed by comparing experimental spectra with related literature and quantum mechanical ab initio calculations. Copyright © 2005 John Wiley & Sons, Ltd.
衍生自 14β-羟基-10-脱乙酰浆果赤霉素 III 的新紫杉烷的结构-活性关系。
影响因子：
7.3
作者：
Ojima,I;Park,YH;Sun,CM;Fenoglio,I;Appendino,G;Pera,P;Bernacki,RJ
通讯作者：
Bernacki,RJ
DOI：
10.1093/jnci/83.4.288
发表时间：
1991-02-20
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
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作者：
RINGEL, I;HORWITZ, SB
通讯作者：
HORWITZ, SB