On the dose to a moving target while employing different IMRT delivery mechanisms
On the dose to a moving target while employing different IMRT delivery mechanisms
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DOI：
10.1016/j.radonc.2007.02.007
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发表时间：
2007-04-01
影响因子：
5.7
通讯作者：
Tome, Wolfgang A.
中科院分区：
文献类型：
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作者：
Ehler, Eric D.;Nelms, Benjamin E.;Tome, Wolfgang A.
背景和目的：比较各种强度调制放射治疗 (IMRT) 方式的移动靶区剂量的时间均匀性：固体强度调制器 (SIM)、分段多叶准直器 (SMLC) 和动态多叶准直器 (DMLC)。 材料和方法：获得两个独立的四维计算机断层扫描数据集。根据呼吸周期各个阶段肿瘤的复合位置确定肿瘤运动核和运动包络线。治疗计划是针对未调制的开放区域、SIM、SMLC 和 DMLC 创建的。运动包络被视为静态目标体积。配备二极管阵列的机器人装置模拟了光束视野 (BEV) 平面中的肿瘤运动。每种方式均经过十次试验将辐射传递到移动目标。确定每个光束角度的平均变异系数 (CV)。结果：未调制开放场、SIM、SMLC 和 DMLC 模式的 CV 范围分别为 0.09% 至 0.15%、0.23% 至 3.14%、1.14% 至 5.51% 和 3.83% 至 8.25%。使用门控时，SIM、SMLC 和 DMLC 的 CV 分别为 0.23% 至 2.31%、0.31% 至 2.97% 和 0.7% 至 4.67%。 结论：SIM 始终为移动目标提供最均匀的剂量，而 DMLC 提供的剂量最少。 SMLC 和 DMLC CV 通过门控输送得到改善。 (c) 2007 Elsevier Ireland Ltd. 保留所有权利。
Background and purposes: To compare the temporal uniformity in dose delivered to a moving target for various intensity modulation radiotherapy (IMRT) modalities: solid intensity modulator (SIM), segmented multi-leaf collimator (SMLC), and dynamic multi-leaf collimator (DMLC).Materials and methods: Two separate four-dimensional computed tomography data sets were obtained. Tumor motion kernels and motion envelopes were determined from composite positions of the tumor in various phases of the breathing cycle. Treatment plans were created for an unmodulated open field, SIM, SMLC, and DMLC. The motion envelope was treated as a static target volume. A robotic apparatus equipped with a diode array simulated the tumor motion in the plane of the beam's eye view (BEV). Radiation was delivered to the moving target over ten trials for each modality. The average coefficient of variation (CV) was determined for each beam angle.Results: The CV ranged from 0.09% to 0.15%, 0.23% to 3.14%, 1.14% to 5.51%, and 3.83% to 8.25% for the unmodulated open field, SIM, SMLC, and DMLC modalities, respectively. With gating, the CV was 0.23% to 2.31%, 0.31% to 2.97%, and 0.7% to 4.67% for SIM, SMLC, and DMLC, respectively.Conclusion: SIM consistently provided the most temporally uniform dose to the moving target while DMLC provided the least. The SMLC and DMLC CV improved with gated delivery. (c) 2007 Elsevier Ireland Ltd. All rights reserved.