Chronic swim stress alters sensitivity to acute behavioral effects of ethanol in mice
Chronic swim stress alters sensitivity to acute behavioral effects of ethanol in mice
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DOI：
10.1016/j.physbeh.2007.01.024
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发表时间：
2007-05-16
影响因子：
2.9
通讯作者：
Holmes, Andrew
中科院分区：
文献类型：
--
作者：
Boyce-Rustay, Janel M.;Cameron, Heather A.;Holmes, Andrew
流行病学数据支持压力、压力相关疾病和酗酒风险之间存在密切联系。然而，压力究竟如何影响对乙醇中毒作用的敏感性或自愿消费乙醇的意愿仍不清楚。本研究评估了雄性 C57BL/6J 小鼠中每天暴露于强迫游泳压力对随后对乙醇的镇静/催眠、低温、共济失调（使用加速旋转棒测量）和抗焦虑样（使用高架十字迷宫测量）的敏感性的影响，以及两瓶选择范例中的乙醇消耗和偏好。还测试了压力对巴比妥戊巴比妥的镇静/催眠作用的影响。结果显示，慢性（十四天）而非急性（一或三天）游泳应激显着增强了 4 g/kg 乙醇的镇静/催眠和降体温作用，但不增强 3 g/kg 乙醇的作用。慢性游泳应激会减弱戊巴比妥的镇静/催眠作用。无论长期性如何，游泳应激都不会改变乙醇的共济失调或抗焦虑样作用，也不会改变应激期间或应激后的乙醇自我给药。这些数据提供了进一步的证据，表明压力以行为选择性方式改变高剂量乙醇的中毒效果。由爱思唯尔公司出版
Epidemiological data support a strong link between stress, stress-related disorders and risk for alcoholism. However, precisely how stress might impact sensitivity to the intoxicating effects of ethanol or the willingness to voluntary consume ethanol remains unclear. The present study assessed the effects of daily exposure to forced swim stress on subsequent sensitivity to the sedative/hypnotic, hypothermic, ataxic (measured using accelerating rotarod), and anxiolytic-like (measured using elevated plus-maze) effects of ethanol, and ethanol consumption and preference in a two-bottle choice paradigm, in male C57BL/6J mice. Stress effects on the sedative/hypnotic effects of the barbiturate pentobarbital were also tested. Results showed that chronic (fourteen days) but not acute (one or three days) swim stress significantly potentiated the sedative/hypnotic and hypothermic effects of 4 g/kg, but not 3 g/kg, ethanol. The sedative/bypnotic effects of pentobarbital were attenuated by chronic swim stress. Irrespective of chronicity, swim stress did not alter the ataxic or anxiolytic-like effects of ethanol, or alter ethanol self-administration either during or after stress. These data provide further evidence that stress alters the intoxicating effects of high doses of ethanol in a behaviorally selective manner. Published by Elsevier Inc.