The Aarhus statement: improving design and reporting of studies on early cancer diagnosis
The Aarhus statement: improving design and reporting of studies on early cancer diagnosis
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DOI：
10.1038/bjc.2012.68
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发表时间：
2012-03-27
影响因子：
8.8
通讯作者：
Neal, R. D.
中科院分区：
文献类型：
--
作者：
Weller, D.;Vedsted, P.;Neal, R. D.
早期诊断是改善癌症患者预后的关键因素。更好地了解诊断前的患者通路是至关重要的，但目前，这一领域的研究缺乏一致的定义和方法。因此，许多早期诊断研究很难解释。成立了一个共识小组，目的是为早期癌症诊断研究人员提供指导和核对表。采用了协商一致的会议方法和名义上的小组技术。这项工作得到了对早期诊断文献的系统回顾的支持，重点是现有的用于测量早期癌症诊断研究中的时间点和间隔的仪器。提出了一系列关于定义和方法方法的建议。这一点得到了一份核对表的补充，早期诊断研究人员可以在设计和进行该领域的研究时使用该清单。奥胡斯清单是早期癌症诊断研究的资源，应该促进定义和方法的更高精确度和透明度。进一步的工作将检查研究人员是否可以很容易地采用核对表，并将在未来的更新中使用对指导的反馈。
Early diagnosis is a key factor in improving the outcomes of cancer patients. A greater understanding of the pre-diagnostic patient pathways is vital yet, at present, research in this field lacks consistent definitions and methods. As a consequence much early diagnosis research is difficult to interpret. A consensus group was formed with the aim of producing guidance and a checklist for early cancer-diagnosis researchers. A consensus conference approach combined with nominal group techniques was used. The work was supported by a systematic review of early diagnosis literature, focussing on existing instruments used to measure time points and intervals in early cancer-diagnosis research. A series of recommendations for definitions and methodological approaches is presented. This is complemented by a checklist that early diagnosis researchers can use when designing and conducting studies in this field. The Aarhus checklist is a resource for early cancer-diagnosis research that should promote greater precision and transparency in both definitions and methods. Further work will examine whether the checklist can be readily adopted by researchers, and feedback on the guidance will be used in future updates.