Assessing directionality and strength of coupling through symbolic analysis: an application to epilepsy patients
Assessing directionality and strength of coupling through symbolic analysis: an application to epilepsy patients
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DOI：
10.1098/rsta.2014.0094
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发表时间：
2015-02-13
期刊：
影响因子：
5
通讯作者：
Dickten, Henning
中科院分区：
文献类型：
--
作者：
Lehnertz, Klaus;Dickten, Henning
从脑电图（EEG）记录中推断相互作用的强度和方向对于提高我们对人类癫痫脑中各种生理和病理生理条件下的动态相互依赖性的理解至关重要。在这里，我们使用的方法从符号分析调查的时间分辨的方式加权和定向，短期到长期的各种大脑区域之间的相互作用，构成癫痫网络。我们的观察点复杂的时空相互依赖性的癫痫过程及其在癫痫发作的产生中的作用，尽管大量减少的复杂信息内容的多天，多通道EEG记录通过符号化。我们讨论了这种方法的局限性和未来潜在的改进。
Inferring strength and direction of interactions from electroencephalographic (EEG) recordings is of crucial importance to improve our understanding of dynamical interdependencies underlying various physiological and pathophysiological conditions in the human epileptic brain. We here use approaches from symbolic analysis to investigate-in a time-resolved manner-weighted and directed, short-to long-ranged interactions between various brain regions constituting the epileptic network. Our observations point to complex spatial-temporal interdependencies underlying the epileptic process and their role in the generation of epileptic seizures, despite the massive reduction of the complex information content of multi-day, multi-channel EEG recordings through symbolization. We discuss limitations and potential future improvements of this approach.