MICB002 and MICB014 protect against rheumatoid arthritis, whereas MICA009 and MICAA6 are associated with rheumatoid arthritis in a Hainan Han Chinese population.
MICB002 and MICB014 protect against rheumatoid arthritis, whereas MICA009 and MICAA6 are associated with rheumatoid arthritis in a Hainan Han Chinese population.
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MICB002 和 MICB014 可预防类风湿性关节炎，而 MICA009 和 MICAA6 与海南汉族人群中的类风湿性关节炎相关
DOI：
10.1111/1756-185x.13302
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发表时间：
2018
影响因子：
2.5
通讯作者：
Wang Fuyan
中科院分区：
文献类型：
--
作者：
Wang Yong;Li Sangsang;Chen Chunjing;Luo Qizhi;Li Yu;Liu Limin;Fu Xiaoling;Yu Ping;Wang Fuyan
目的:。类风湿性关节炎（RA）作为一种炎症性自身免疫性疾病，影响滑膜关节以及其他器官和组织。由于在RA患者中观察到MIC分子的异常表达，MIC基因型可能在RA的发生发展中起一定作用。为了探讨MICA和MICB多态性与海南岛汉族人群RA的关系，我们对172例RA和137例健康对照进行了MICA和MICB基因分型。结果表明，MICB*002和MICB*014在RA患者中的表达频率低于对照组（P = 0.000, 0.005）， MICA*009和MICA*A6在RA患者中的表达比例高于对照组（P = 0.005）。不同的MIC变异可能以不同的方式调节RA疾病的自身免疫反应，因此可作为保护或危险因素。
AIM:.Rheumatoid arthritis (RA) as an inflammatory autoimmune disease affects the synovial joints as well as other organs and tissues. Since aberrant expression of MIC molecules has been observed in RA patient, MIC genotypes might play certain roles in the development of RA...METHOD:.To explore the association of MICA and MICB polymorphisms with RA in a Han Chinese population in Hainan Island, samples from 172 RA and 137 healthy controls were genotyped for MICA and MICB...RESULTS:.Our results indicated that MICB*002 and MICB*014 were less frequent in RA patients than in controls (P = 0.000, 0.005) while there were higher percentages of RA patients carrying MICA*009 and MICA*A6 (P = 0.005)...CONCLUSION:.Different MIC variants might modulate the autoimmune reaction differently in RA disease and therefore serve as protective or risk factors.