Comparison of the induced fields using different coil configurations during deep transcranial magnetic stimulation.
Comparison of the induced fields using different coil configurations during deep transcranial magnetic stimulation.
复制标题
深部经颅磁刺激过程中不同线圈配置的感应场比较
DOI：
10.1371/journal.pone.0178422
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Ueno S
中科院分区：
文献类型：
--
作者：
Lu M;Ueno S
通过经颅磁刺激（TMS）刺激更深的大脑结构在奖励和动机机制的研究中发挥作用，这可能有利于治疗几种神经和精神疾病。然而，深部经颅磁刺激（dTMS）在大脑中诱导的电场分布仍然是未知的。本文对双锥线圈、H型线圈和晕圆组合线圈进行了数值设计。采用阻抗法数值计算了在一个基于解剖学的真实头部模型中应用dTMS线圈后的磁通密度、感应电场的分布。结果与标准8字形（Fo 8）线圈进行了比较。仿真结果表明，双锥，H-和HCA线圈具有显着的深场渗透相比，传统的Fo 8线圈，在牺牲的诱导更高和更广泛的传播电场在表层皮层区域。双锥线圈和HCA线圈具有比H线圈更好的刺激脑深部亚区的能力。同时，双锥和HCA线圈都增加了视神经兴奋的风险。我们的研究结果表明，尽管dTMS线圈为与脑深部功能障碍相关的精神和神经疾病的研究和临床应用提供了新的工具，但针对特定临床应用选择最合适的线圈设置应基于刺激深度和病灶之间的平衡评估。
Stimulation of deeper brain structures by transcranial magnetic stimulation (TMS) plays a role in the study of reward and motivation mechanisms, which may be beneficial in the treatment of several neurological and psychiatric disorders. However, electric field distributions induced in the brain by deep transcranial magnetic stimulation (dTMS) are still unknown. In this paper, the double cone coil, H-coil and Halo-circular assembly (HCA) coil which have been proposed for dTMS have been numerically designed. The distributions of magnetic flux density, induced electric field in an anatomically based realistic head model by applying the dTMS coils were numerically calculated by the impedance method. Results were compared with that of standard figure-of-eight (Fo8) coil. Simulation results show that double cone, H- and HCA coils have significantly deep field penetration compared to the conventional Fo8 coil, at the expense of induced higher and wider spread electrical fields in superficial cortical regions. Double cone and HCA coils have better ability to stimulate deep brain subregions compared to that of the H-coil. In the mean time, both double cone and HCA coils increase risk for optical nerve excitation. Our results suggest although the dTMS coils offer new tool with potential for both research and clinical applications for psychiatric and neurological disorders associated with dysfunctions of deep brain regions, the selection of the most suitable coil settings for a specific clinical application should be based on a balanced evaluation between stimulation depth and focality.