Evaluation of three-dimensional finite element-based deformable registration of pre- and intraoperative prostate imaging
Evaluation of three-dimensional finite element-based deformable registration of pre- and intraoperative prostate imaging
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DOI：
10.1118/1.1414009
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发表时间：
2001-12-01
期刊：
影响因子：
3.8
通讯作者：
Tempany, CMC
中科院分区：
文献类型：
--
作者：
Bharatha, A;Hirose, M;Tempany, CMC
在这份报告中，我们评估了一种图像配准技术，该技术可以通过术前图像的变形匹配来提高术中图像数据的信息量。本研究将前列腺术前1.5T磁共振(MR)图像与术中0.5T图像配准。该方法使用生物力学有限元模型进行刚体和非刚体配准。术中使用直肠内线圈，仰卧位进行1.5T磁共振成像。患者处于切开取石位，直肠闭孔器就位。我们以前观察到，患者体位和直肠充盈的这些变化会导致前列腺的形状变化。将术前1.5T的前列腺亚结构[即中央腺(CG)和外周带(PZ)]图像与术中0.5T的MR图像配准，可以方便地分割腺体的亚结构，为放射治疗计划提供依据。在从10个连续的MR引导的近距离放射治疗病例中获得的图像中创建并验证了手动分割腺体的数据集之后，我们进行了一组实验来评估我们的假设，即所提出的配准系统可以显著提高总腺体(TG)、CG和PZ的匹配质量。结果表明，该方法显著改善了匹配质量(与刚性配准相比)，将骰子相似系数(DSC)从TG、CG和PZ的预匹配系数分别从0.81、0.78和0.59提高到0.94、0.86和0.76。可变形登记还改进了基于积分的登记协议措施。CG和PZ体积不会因配准而改变，这表明该方法保持了前列腺的生物力学拓扑。虽然这一策略被测试用于MRI引导的近距离放射治疗，但这些实验的初步结果表明，它可能适用于其他环境，如经直肠超声引导的治疗，在这些环境中，术前MRI的整合可能会对治疗计划和指导产生重大影响。(C)2001年美国医学物理学家协会。
In this report we evaluate an image registration technique that can improve the information content of intraoperative image data by deformable matching of preoperative images. In this study, pretreatment 1.5 tesla (T) magnetic resonance (MR) images of the prostate are registered with 0.5 T intraoperative images. The method involves rigid and nonrigid registration using biomechanical finite element modeling. Preoperative 1.5 T MR imaging is conducted with the patient supine, using an endorectal coil, while intraoperatively. the patient is in the lithotomy position with a rectal obturator in place. We have previously observed that these changes in patient position and rectal filling produce a shape change in the prostate. The registration of 1.5 T preoperative images depicting the prostate substructure [namely central gland (CG) and peripheral zone (PZ)] to 0.5 T intraoperative MR images using this method can facilitate the segmentation of the substructure of the gland for radiation treatment planning. After creating and validating a dataset of manually segmented glands from images obtained in ten sequential MR-guided brachytherapy cases, we conducted a set of experiments to assess our hypothesis that the proposed registration system can significantly improve the quality of matching of the total gland (TG), CG, and PZ. The results showed that the method statistically-significantly improves the quality of match (compared to rigid registration), raising the Dice similarity coefficient (DSC) from prematched coefficients of 0.81, 0.78, and 0.59 for TG, CG, and PZ, respectively, to 0.94, 0.86, and 0.76. A point-based measure of registration agreement was also improved by the deformable registration. CG and PZ volumes are not changed by the registration, indicating that the method maintains the biomechanical topology of the prostate. Although this strategy was tested for MRI-guided brachytherapy, the preliminary results from these experiments suggest that it may be applied to other settings such as transrectal ultrasound-guided therapy, where the integration of preoperative MRI may have a significant impact upon treatment planning and guidance. (C) 2001 American Association of Physicists in Medicine.