Significance of Metallothionein Expression in Liver Disease
Significance of Metallothionein Expression in Liver Disease
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DOI：
10.2174/1389201011314040006
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发表时间：
2013-03-01
影响因子：
2.8
通讯作者：
Nakajima, Katsuyuki
中科院分区：
文献类型：
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作者：
Nagamine, Takeaki;Nakajima, Katsuyuki
肝金属硫蛋白(MT)的表达具有多种异构体和不同的细胞定位，是肝病临床发病机制的有用标志物。在镉、四氯化碳或对乙酰氨基酚引起的急性肝脏毒性中，MT通过清除自由基发挥保护作用。在慢性丙型肝炎患者中，肝脏MT水平似乎是与丙型肝炎病毒感染严重程度相关的生物学因素，并与干扰素治疗的良好反应有关。在肝脏中表达乙肝表面抗原的转基因小鼠会出现肝细胞损伤、炎症、再生、增殖，最终出现肿瘤。MT亚型MT-1有助于减轻乙肝病毒引起的肝炎。分析慢性乙型病毒性肝炎患者肝脏中MT基因的表达有助于了解不同肝病的特点和判断疾病进展。63%的肿瘤组织中MT-1G亚型在肝细胞癌中的表达较癌旁肝组织明显下调。MT与锌交换调控P53折叠有关。因此，MT可能在肝细胞癌的发病机制中起一定作用。总体而言，MT与多种肝病有关。
Hepatic metallothionein (MT) expression, with various isoforms, and varying cellular localizations is a useful marker for clinico-pathogenesis of liver diseases. In acute liver toxicity caused by cadmium, carbon tetrachloride, or acetaminophen, MT plays a protective role, via the scavenging of radical species. In chronic hepatitis C patients, hepatic MT levels appear to be a biological factor associated with the severity of HCV infection, and are associated with a better response to IFN therapy. Transgenic mice that express HBsAg in the liver show hepatocellular damage, inflammation, regeneration, hyperplasia, and, eventually, neoplasia. The MT isoform, MT-1 help mitigate HBV-induced hepatitis. Analysis of MT gene expression in the livers of chronic hepatitis B patients is useful for understanding the features of distinct liver diseases and for judging disease progression. A profound down-regulation of isoform MT-1G in hepatocellular carcinoma was observed in 63% of tumors relative to the adjacent nonmalignant liver. MT has been implicated in the control of p53 folding with zinc exchange. Therefore, it appears MT may play a role in the pathogenesis of hepatocellular carcinoma. Overall MT is linked to a variety of liver diseases.